ZW10 anticorps (Alexa Fluor 488)

N° du produit ABIN920492

Détail du produit anti-ZW10 anticorps (Alexa Fluor 488)

Antigène: ZW10 (Zw10 Kinetochore Protein (ZW10))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZW10 est conjugé à/à la Alexa Fluor 488

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Homologie: Human,Mouse,Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from mouse ZW10

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur ZW10

Antigène: ZW10 (Zw10 Kinetochore Protein (ZW10))

Abstract: ZW10 Produits

Synonymes: anticorps HZW10, anticorps KNTC1AP, anticorps 6330566F14Rik, anticorps MmZw10, anticorps zw10 kinetochore protein, anticorps ZW10, anticorps Zw10

Sujet:

Synonyms: Centromere/kinetochore protein zw10, Centromere/kinetochore protein zw10 homolog, HZW 10, HZW10, Kinetochore associated homolog, KNTC1AP, MGC149821, Zeste White 10, Zeste white 10 homolog, ZW 10, ZW 10, centromere/kinetochore protein, ZW 10 kinetochore associated homolog, ZW10 Drosophila homolog centromere/kinetochore protein, ZW10 homolog centromere/kinetochore protein Drosophila, ZW10 homolog centromere/kinetochore protein, ZW10 kinetochore associated homolog, ZW10_MOUSE.

Background: The mitotic checkpoint ensures that chromosomes are divided equally between daughter cells and is a primary mechanism preventing the chromosome instability often seen in aneuploid human tumors. This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. The encoded protein binds to centromeres during the prophase, metaphase, and early anaphase cell division stages and to kinetochore microtubules during metaphase. It is part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. In mitotic human cells ZW10 resides in a complex with Rod and Zwilch, whereas another ZW10 partner, Zwint-1, is part of a separate complex of structural kinetochore components including Mis12 and Ndc80-Hec1. Zwint-1 is critical for recruiting ZW10 to unattached kinetochores. Depletion from human cells demonstrates that the ZW10 complex is essential for stable binding of a Mad1-Mad2 complex to unattached kinetochores. Thus, ZW10 functions as a linker between the core structural elements of the outer kinetochore and components that catalyze generation of the mitotic checkpoint-derived "stop anaphase" inhibitor.

ID gène: 9183