MDM4-binding Protein anticorps (N-Term)

N° du produit ABIN926007

Cet anticorps anti-MDM4-binding Protein est un anticorps Lapin Polyclonal détectant MDM4-binding Protein dans WB. Adapté pour Humain, Boeuf (Vache) et Chien.

Aperçu rapide pour MDM4-binding Protein anticorps (N-Term) (ABIN926007)

Antigène: MDM4-binding Protein (MDM4) (Mdm4-binding Protein (MDM4))

Reactivité: Humain, Boeuf (Vache), Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MDM4-binding Protein est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-MDM4-binding Protein anticorps

Épitope: N-Term

Réactivité croisée: Chien, Boeuf (Vache)

Immunogène: MDM4 antibody was raised in rabbit using the N terminal of MDM4 as the immunogen

Information d'application

Indications d'application: Optimal conditions should be determined by the investigator.

Commentaires:

MDM4 Blocking Peptide, , is also available for use as a blocking control in assays to test for specificity of this MDM4 antibody

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 100 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Détails sur MDM4-binding Protein

Antigène: MDM4-binding Protein (MDM4) (Mdm4-binding Protein (MDM4))

Autre désignation: MDM4

Sujet: MDM4 inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. inhibits degradation of MDM2. It can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation and apoptotic functions. The human MDM4 gene, which plays a role in apoptosis, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins contain, is located in the C-terminal region of the protein. The mRNA is expressed at a high level in thymus and at lower levels in all other tissues tested. MDM4 protein produced by in vitro translation interacts with p53 via a binding domain located in the N-terminal region of the MDM4 protein. MDM4 shows significant structural similarity to p53-binding protein MDM2. Synonyms: Polyclonal MDM4 antibody, Anti-MDM4 antibody, Mdm4 p53 binding protein homolog, mouse antibody, DKFZp781B1423 antibody, MDMX antibody, MGC132766 antibody, MRP1 antibody.

Pathways: Cycle Cellulaire