Cullin 2 anticorps (Middle Region)

N° du produit ABIN926903

Détail du produit anti-Cullin 2 anticorps

Antigène: Cullin 2 (CUL2)

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Xenopus laevis

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cullin 2 est non-conjugé

Application: Western Blotting (WB)

Réactivité croisée: Souris, Rat (Rattus), Chien, Boeuf (Vache), Grenouille

Purification: Purified

Immunogène: CUL2 antibody was raised in rabbit using the middle region of CUL2 as the immunogen

Information d'application

Indications d'application: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Commentaires:

CUL2 Blocking Peptide, catalog no. 33R-3799, is also available for use as a blocking control in assays to test for specificity of this CUL2 antibody

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Détails sur Cullin 2

Antigène: Cullin 2 (CUL2)

Autre désignation: CUL2 (CUL2 Produits)

Synonymes: anticorps cul2, anticorps Cullin-2, anticorps fj48a06, anticorps wu:fj48a06, anticorps cullin-2, anticorps LOC100221330, anticorps 1300003D18Rik, anticorps 4932411N15Rik, anticorps AI327301, anticorps mKIAA4106, anticorps ATCUL2, anticorps F22D16.2, anticorps F22D16_2, anticorps cullin 2, anticorps cullin 2, anticorps cullin-2, anticorps putative cullin-2 (cul-2), anticorps cullin 2 L homeolog, anticorps Cullin-2, anticorps cul2, anticorps CUL2, anticorps PTRG_05231, anticorps Smp_079740, anticorps LOC100550749, anticorps Cul2, anticorps cul2.L, anticorps cul-2

Sujet: CUL2 is a core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. This protein may serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 By similarity. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF). Synonyms: Polyclonal CUL2 antibody, Anti-CUL2 antibody, cullin 2 antibody, MGC131970 antibody.

Pathways: M Phase, Asymmetric Protein Localization, SARS-CoV-2 Protein Interactome