Insulin Receptor anticorps (Middle Region)

N° du produit ABIN926933

L’anticorps Lapin Polyclonal anti-Insulin Receptor a été validé pour WB et IHC. Il convient pour détecter Insulin Receptor dans des échantillons de Humain, Souris, Rat, Chien, Lapin, Poisson zèbre (Danio rerio) et Xenopus laevis.

Aperçu rapide pour Insulin Receptor anticorps (Middle Region) (ABIN926933)

Antigène: Insulin Receptor (INSR)

Reactivité: Humain, Souris, Rat, Chien, Lapin, Poisson zèbre (Danio rerio), Xenopus laevis

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Insulin Receptor est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Insulin Receptor anticorps

Épitope: Middle Region

Réactivité croisée: Souris, Rat (Rattus), Chien, Lapin, Poisson zebré (Brachydanio rerio), Grenouille

Purification: Purified

Immunogène: INSR antibody was raised in rabbit using the middle region of INSR as the immunogen

Information d'application

Indications d'application: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Commentaires:

INSR Blocking Peptide, (ABIN5614204), is also available for use as a blocking control in assays to test for specificity of this INSR antibody

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Détails sur Insulin Receptor

Antigène: Insulin Receptor (INSR)

Autre désignation: INSR

Sujet: This receptor binds insulin and has a tyrosine-protein kinase activity. Isoform Short has a higher affinity for insulin. INSR mediates the metabolic functions of insulin. INSR binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K). INSR can activate PI3K either directly by binding to the p85 regulatory subunit, or indirectly via IRS1. When present in a hybrid receptor with IGF1R, it binds IGF1. Synonyms: Polyclonal INSR antibody, Anti-INSR antibody, insulin receptor antibody, CD220 antibody, HHF5 antibody.

Pathways: Signalisation NF-kappaB, Signalisation RTK, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity