Crk anticorps

N° du produit ABIN931057

Cet anticorps Souris Monoclonal détecte spécifiquement Crk dans DB. Il présente une réactivité envers Humain.

Aperçu rapide pour Crk anticorps (ABIN931057)

Antigène: Crk (CRK) (V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian) (CRK))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Crk est non-conjugé

Application: Dot Blot (DB)

Clone: 2210C1a

Détail du produit anti-Crk anticorps

Réactivité croisée: Humain

Réactivité croisée (Details): Other species not studied.

Purification: Protein G affinity chromatography

Immunogène: CRK antibody was raised in mouse using recombinant Human V-Crk Sarcoma Virus Ct10 Oncogene Homolog (Avian)

Isotype: IgG1

Information d'application

Indications d'application: Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: Lot specific

Buffer: CRK antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1 % bovine serum albumin (BSA) and 0.05 % sodium azide (NaN3 ).

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2-8 °C for up to one year. We recommend long term storage at -20 °C.

Détails sur Crk

Antigène: Crk (CRK) (V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian) (CRK))

Autre désignation: CRK

Sujet: The CRK gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. This protein has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Synonyms: Monoclonal CRK antibody, Anti-CRK antibody, V-crk sarcoma virus CT10 oncogene homolog antibody, CRKII antibody.

Pathways: Neurotrophin Signaling Pathway, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor