HIRA anticorps

N° du produit ABIN932202

Cet anticorps anti-HIRA Monoclonal Souris (Clone 374C6a) (ABIN932202) détecte spécifiquement HIRA dans ICC et DB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour HIRA anticorps (ABIN932202)

Antigène: HIRA (HIR Histone Cell Cycle Regulation Defective Homolog A (HIRA))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp HIRA est non-conjugé

Application: Immunocytochemistry (ICC), Dot Blot (DB)

Clone: 374C6a

Détail du produit anti-HIRA anticorps

Réactivité croisée: Humain

Réactivité croisée (Details): Other species not studied.

Purification: Protein G affinity chromatography

Immunogène: TUPLE1 antibody was raised in mouse using recombinant H.Sapiens Tup1-Like Enhancer Of Split Gene 1 (Tuple1)

Isotype: IgG2a

Information d'application

Indications d'application: ICC: 2-100 µg/mL
Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: Lot specific

Buffer: TUPLE1 antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1 % bovine serum albumin (BSA) and 0.05 % sodium azide (NaN3 ).

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2-8 °C for up to one year. We recommend long term storage at -20 °C.

Détails sur HIRA

Antigène: HIRA (HIR Histone Cell Cycle Regulation Defective Homolog A (HIRA))

Autre désignation: TUPLE1

Sujet: This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. Synonyms: Monoclonal TUPLE1 antibody, Anti-TUPLE1 antibody, TUP1-like enhancer of split protein 1 antibody.

Pathways: Chromatin Binding