RANKL anticorps

N° du produit ABIN933803

L’anticorps anti-RANKL Monoclonal Souris est utilisé pour la détection de RANKL dans des échantillons de Humain. Il a été validé pour WB, ELISA et InhibAb.

Aperçu rapide pour RANKL anticorps (ABIN933803)

Antigène: RANKL (TNFSF11) (Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp RANKL est non-conjugé

Application: Western Blotting (WB), ELISA, Blocking Antibody (InhibAb)

Clone: M912290

Détail du produit anti-RANKL anticorps

Immunogène: RANKL antibody was raised in mouse using highly pure recombinant human sRANK ligand as the immunogen.

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal conditions should be determined byt he investigator.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized from PBS.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at -20 °C until reconstitution. Following reconstitution product may be stored at 4 °C in the short term. For long term storage aliquot and freeze at -20 °C.

Détails sur RANKL

Antigène: RANKL (TNFSF11) (Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))

Autre désignation: RANKL

Sujet: RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic-cell-membrane protein, which by interacting with RANKL augments the ability of dendritic cells to stimulate naïve T-cell proliferation in a mixed lymphocyte reaction, to promote the survival of RANK + T cells, and to regulate T-cell-dependent immune response. RANKL, which is expressed in a variety of cells including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal cells, is also capable of interacting with a decoy receptor called OPG. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. Synonyms: Monoclonal RANKL antibody, Anti-RANKL antibody, soluble Receptor Activator of NFkB Ligand antibody, TNFSF11 antibody, TRANCE antibody, TNF-related activation-induced cytokine antibody, OPGL antibody, ODF antibody, Osteoclast differentiation factor antibody.

Poids moléculaire: 19.4 kDa (predicted detection band MW)

Pathways: Signalisation NF-kappaB