p21 anticorps

N° du produit ABIN94444

Cet anticorps Souris Monoclonal détecte spécifiquement p21 dans ELISA, IHC (p) et ICC. Il présente une réactivité envers Humain et Non-Human Primate et a été mentionné dans 2+ publications.

Aperçu rapide pour p21 anticorps (ABIN94444)

Antigène: p21 (CDKN1A) (Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A))

Reactivité: Humain, Non-Human Primate

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp p21 est non-conjugé

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Clone: WA-1

Détail du produit anti-p21 anticorps

Fonction: Anti-p21Waf1 Purified

Specificité: The antibody WA-1 reacts with p21 protein (Waf1, Cip1, SDI 1, intracellular antigen), a 21 kDa tumour suppressor, which inhibits the activity of cyclin-dependent family kinases and of proliferating cell nuclear antigen.

Réactivité croisée (Details): Human, Non-Human Primates

Purification: Purified by protein-A affinity chromatography.

Pureté: > 95 % (by SDS-PAGE)

Immunogène: Human p21 protein

Isotype: IgG1

Information d'application

Indications d'application: Immunohistochemistry (paraffin sections): Positive tissue: colon carcinoma.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Références pour anticorps anti-p21 (ABIN94444)

Palumbo, Gogliettino, Cocca, Iannitti, Sandomenico, Ruvo, Balestrieri, Rossi, Palmieri: "APEH Inhibition Affects Osteosarcoma Cell Viability via Downregulation of the Proteasome." dans: International journal of molecular sciences, Vol. 17, Issue 10, (2017) (PubMed).

Kolár, Murray, Scott, Harrison, Vojt?sek, Dusek: "Relation of Bcl-2 expression to androgen receptor, p21WAF1/CIP1, and cyclin D1 status in prostate cancer." dans: Molecular pathology : MP, Vol. 53, Issue 1, pp. 15-8, (2000) (PubMed).

Détails sur p21

Antigène: p21 (CDKN1A) (Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A))

Autre désignation: p21Waf1

Sujet: Cyclin dependent kinase inhibitor 1A,The tumour suppressor p21Waf1 (wild-type p53-activated fragment 1, also known as Cip1, Cdk interacting protein, or SDI 1) is a cyclin-dependent kinase (Cdk) inhibitor, which is expressed by involvement of p53, Egr-1, AP2, STATs or other transcription factors upon various stimuli resulting in cell cycle arrest. Through its N-terminal domain p21Waf1 inhibits Cdk activity, whereas through the C-terminal domain it inhibits the activity of PCNA (proliferating cell nuclear antigen) to activate DNA replication. Cytosolic location of p21 counteracts its inhibitory activities.,CDKN1A, CIP1, CAP20

ID gène: 1026

UniProt: P38936

Pathways: Signalisation p53, Signalisation PI3K-Akt, Cycle Cellulaire, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Hepatitis C, Synthesis of DNA, Autophagy