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p21 anticorps
CDKN1A
Reactivité: Humain, Non-Human Primate
ELISA, IHC (p), ICC
Hôte: Souris
Monoclonal
WA-1
unconjugated
Détail du produit anti-p21 anticorps
(cache)
Antigène
Voir toutes p21 (CDKN1A) Anticorps
p21 (CDKN1A)
(Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A))
Reactivité
Toutes les réactivités sur p21 Anticorps
Humain, Non-Human Primate
Hôte
Toutes les hôtes sur p21 Anticorps
Souris
Clonalité
Toutes les clonalités sur p21 Anticorps
Monoclonal
Conjugué
Tous les conjugués à travers p21 Anticorps
Cet anticorp p21 est non-conjugé
Application
Tous les applications à travers p21 Anticorps.
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
Specificité
The antibody WA-1 reacts with p21 protein (Waf1, Cip1, SDI 1, intracellular antigen), a 21 kDa tumour suppressor, which inhibits the activity of cyclin-dependent family kinases and of proliferating cell nuclear antigen.
Réactivité croisée (Details)
Human, Non-Human Primates
Purification
Purified by protein-A affinity chromatography.
Pureté
> 95 % (by SDS-PAGE)
Immunogène
Human p21 protein
Clone
WA-1
Isotype
IgG1
Top Product
Discover our top product CDKN1A Anticorps primaire
Alternatives
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anti-Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) (AA 21-100) antibody
CDKN1A
Reactivité: Humain, Souris, Rat, Mouton
WB, ELISA, FACS, IHC (p), IF (cc), IF (p), ICC, IHC (fro)
Hôte: Lapin
Polyclonal
unconjugated
Information d'application
(cache)
Indications d'application
Immunohistochemistry (paraffin sections): Positive tissue: colon carcinoma.
Restrictions
For Research Use only
Stockage
(cache)
Concentration
1 mg/mL
Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Do not freeze.
Stock
4 °C
Stockage commentaire
Store at 2-8°C. Do not freeze.
Références pour anticorps anti-p21 (ABIN94444)
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Palumbo, Gogliettino, Cocca, Iannitti, Sandomenico, Ruvo, Balestrieri, Rossi, Palmieri : "APEH Inhibition Affects Osteosarcoma Cell Viability via Downregulation of the Proteasome. " dans: International journal of molecular sciences , Vol. 17 , Issue 10 , (2017 ) (PubMed ).
Kolár, Murray, Scott, Harrison, Vojt?sek, Dusek : "Relation of Bcl-2 expression to androgen receptor, p21WAF1/CIP1, and cyclin D1 status in prostate cancer. " dans: Molecular pathology : MP , Vol. 53 , Issue 1 , pp. 15-8 , (2000 ) (PubMed ).
Détails sur p21
(cache)
Antigène
p21 (CDKN1A)
(Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A))
Autre désignation
p21Waf1 (CDKN1A Produits )
Synonymes
anticorps CCND1, anticorps CDKN1A, anticorps CAP20, anticorps CDKN1, anticorps CIP1, anticorps MDA-6, anticorps P21, anticorps SDI1, anticorps WAF1, anticorps p21CIP1, anticorps CDKI, anticorps Cdkn1, anticorps Waf1, anticorps mda6, anticorps p21Cip1, anticorps p21WAF, anticorps Cip1, anticorps UV96, anticorps p21, anticorps cip1, anticorps p16Xic2, anticorps sdi1, anticorps waf1, anticorps cap20, anticorps cdkn1, anticorps mda-6, anticorps p21cip1, anticorps si:ch1073-48m5.2, anticorps KRAS2, anticorps p21ras, anticorps cyclin D1, anticorps cyclin dependent kinase inhibitor 1A, anticorps cyclin-dependent kinase inhibitor 1A (P21), anticorps cyclin-dependent kinase inhibitor 1A, anticorps cyclin-dependent kinase inhibitor 1A L homeolog, anticorps cyclin-dependent kinase inhibitor 1, anticorps KRAS proto-oncogene, GTPase, anticorps CCND1, anticorps CDKN1A, anticorps Cdkn1a, anticorps cdkn1a.L, anticorps cki1, anticorps cdkn1a, anticorps KRAS
Sujet
Cyclin dependent kinase inhibitor 1A,The tumour suppressor p21Waf1 (wild-type p53-activated fragment 1, also known as Cip1, Cdk interacting protein, or SDI 1) is a cyclin-dependent kinase (Cdk) inhibitor, which is expressed by involvement of p53, Egr-1, AP2, STATs or other transcription factors upon various stimuli resulting in cell cycle arrest. Through its N-terminal domain p21Waf1 inhibits Cdk activity, whereas through the C-terminal domain it inhibits the activity of PCNA (proliferating cell nuclear antigen) to activate DNA replication. Cytosolic location of p21 counteracts its inhibitory activities.,CDKN1A, CIP1, CAP20
ID gène
1026
UniProt
P38936
Pathways
Signalisation p53 , Signalisation PI3K-Akt , Cycle Cellulaire , AMPK Signaling , Fc-epsilon Receptor Signaling Pathway , EGFR Signaling Pathway , Neurotrophin Signaling Pathway , Mitotic G1-G1/S Phases , DNA Replication , Hepatitis C , Synthesis of DNA , Autophagy
Vus récemment
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