HLA B7 anticorps (Middle Region)

N° du produit ABIN952748

Détail du produit anti-HLA B7 anticorps

Antigène: HLA B7 (HLA Class I B7 Alpha (HLA B7))

Épitope: AA 184-212, Middle Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HLA B7 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody recognizes Human HLA class I B7 alpha / HLA-B (Center).

Purification: Protein A column, followed by peptide affinity purification

Immunogène: KLH conjugated synthetic peptide between 184-212 amino acids from the Central region of human HLA-B

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur HLA B7

Antigène: HLA B7 (HLA Class I B7 Alpha (HLA B7))

Abstract: HLA B7 Produits

Synonymes: anticorps AS, anticorps HLAB, anticorps SPDA1, anticorps major histocompatibility complex, class I, B, anticorps HLA-B

Sujet: HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.Synonyms: B-7 alpha chain, HLA class I histocompatibility antigen, HLAB, MHC class I antigen B7

Poids moléculaire: 40460 Da

ID gène: 3106

NCBI Accession: NP_005505