CHEK2 anticorps

N° du produit ABIN965891

4+ publications sont disponibles pour ce produit. L’anticorps anti-CHEK2 Polyclonal produit chez le Lapin a été validé pour IHC. Il convient pour la détection de CHEK2 dans des échantillons provenant de Humain, Souris et Rat. }

Aperçu rapide pour CHEK2 anticorps (ABIN965891)

Antigène: CHEK2 (Checkpoint Kinase 2 (CHEK2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CHEK2 est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-CHEK2 anticorps

Specificité: Chk2 (Ab-68) antibody detects endogenous levels of total Chk2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: The antiserum was produced against synthesized non-phosphopeptide derived from human Chk2 around the phosphorylation site of threonine 68.

Information d'application

Indications d'application: WB: 1:500~1:1000
IHC: 1:50~1:100.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 100ug/100ul.

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Références pour anticorps anti-CHEK2 (ABIN965891)

Bhoumik, Takahashi, Breitweiser, Shiloh, Jones, Ronai: "ATM-dependent phosphorylation of ATF2 is required for the DNA damage response." dans: Molecular cell, Vol. 18, Issue 5, pp. 577-87, (2005) (PubMed).

Gorgoulis, Vassiliou, Karakaidos, Zacharatos, Kotsinas, Liloglou, Venere, Ditullio, Kastrinakis, Levy, Kletsas, Yoneta, Herlyn, Kittas, Halazonetis: "Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions." dans: Nature, Vol. 434, Issue 7035, pp. 907-13, (2005) (PubMed).

Jin, Kurosu, Yamaguchi, Arai, Miura: "Hematopoietic cytokines enhance Chk1-dependent G2/M checkpoint activation by etoposide through the Akt/GSK3 pathway to inhibit apoptosis." dans: Oncogene, Vol. 24, Issue 12, pp. 1973-81, (2005) (PubMed).

Li, Stern: "Regulation of CHK2 by DNA-dependent protein kinase." dans: The Journal of biological chemistry, Vol. 280, Issue 12, pp. 12041-50, (2005) (PubMed).

Détails sur CHEK2

Antigène: CHEK2 (Checkpoint Kinase 2 (CHEK2))

Autre désignation: CHK2

Pathways: Signalisation p53, Apoptose, Cycle Cellulaire