HTR2A anticorps (C-Term)

N° du produit ABIN966325

Cet anticorps Polyclonal détecte spécifiquement HTR2A dans WB et IHC (p). Il présente une réactivité avec des échantillons de Humain, Rat et Souris. Il a été cité dans 2+ publications.

Aperçu rapide pour HTR2A anticorps (C-Term) (ABIN966325)

Antigène: HTR2A (5-Hydroxytryptamine (serotonin) Receptor 2A (HTR2A))

Reactivité: Humain, Rat, Souris

Hôte: Veuillez nous consulter SVP

Clonalité: Polyclonal

Conjugué: Cet anticorp HTR2A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-HTR2A anticorps

Épitope: AA 418-432, C-Term

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminal of human HTR2A (418-432 aa), different from the mouse sequence by one amino acid.

Information d'application

Restrictions: For Research Use only

Stockage

Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Stock: -20 °C

Références pour anticorps anti-HTR2A (ABIN966325)

Elphick, Querbes, Jordan, Gee, Eash, Manley, Dugan, Stanifer, Bhatnagar, Kroeze, Roth, Atwood: "The human polyomavirus, JCV, uses serotonin receptors to infect cells." dans: Science (New York, N.Y.), Vol. 306, Issue 5700, pp. 1380-3, (2004) (PubMed).

Cook, Fletcher, Wainwright, Marks, Yan, Leventhal: "Primary structure of the human platelet serotonin 5-HT2A receptor: identify with frontal cortex serotonin 5-HT2A receptor." dans: Journal of neurochemistry, Vol. 63, Issue 2, pp. 465-9, (1994) (PubMed).

Détails sur HTR2A

Antigène: HTR2A (5-Hydroxytryptamine (serotonin) Receptor 2A (HTR2A))

Autre désignation: HTR2A

Sujet: The mammalian HTR2A 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR). This is the main excitatory receptor subtype among the GPCRs for serotonin (5-HT), although 5-HT2A may also have an inhibitory effect on certain areas such as the visual cortex and the orbit frontal cortex. This receptor was given importance first as the target of psychedelic drugs like LSD. Later it came back to prominence because it was also found to be mediating, at least partly, the action of many antipsychotic drugs, especially the atypical ones.5-HT2A also happens to be a necessary receptor for the spread of the human polyoma virus called JC virus. Sparkes et al. (1991) concluded that the gene is located on 13q14-q21 in man and on chromosome 14 in the mouse.

Pathways: Signalistation JAK/STAT, Inositol Metabolic Process, Regulation of Carbohydrate Metabolic Process