IGF1R anticorps (Insulin-Like Growth Factor 1 Receptor)

Details for Product anti-IGF1R Antibody No. ABIN966348
Antigène
  • CD221
  • IGFIR
  • IGFR
  • JTK13
  • IGFIRC
  • IGFR1
  • IGF-1R
  • IGF1R
  • DKFZp469I0618
  • igf-1r
  • xIGF-1R
  • xIGFR
  • xigf1r
  • A330103N21Rik
  • D930020L01
  • hyft
  • igf-ir
  • IGF-IRa
  • sb:eu1090
  • wu:fi20b10
  • insulin like growth factor 1 receptor
  • insulin-like growth factor 1 receptor
  • insulin-like growth factor I receptor
  • insulin like growth factor 1 receptor S homeolog
  • insulin-like growth factor 1a receptor
  • IGF1R
  • Igf1r
  • igf1r
  • LOC780503
  • LOC100136427
  • igf1r.S
  • igf1ra
Reactivité
Humain
564
319
302
21
19
18
12
11
6
4
4
3
2
2
1
Hôte
466
98
2
2
1
Clonalité
Monoclonal
Conjugué
Cet anticorp IGF1R est non-conjugé
23
19
16
15
14
14
14
14
14
14
8
8
8
8
8
7
6
2
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
358
164
151
104
89
68
61
49
15
13
8
6
3
3
2
1
1
Options
Immunogène Ni-NTA purified truncated recombinant IGF1R-His expressed in E. Coli strain BL21 (DE3)
Isotype IgG2b
Purification Crude ascites.
Plasmids, Primers & others Plasmids, Primers & others IGF1R products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation IGF1R (IGF1R Antibody Extrait)
Sujet IGF1R(insulin-like growth factor 1 receptor), a transmembrane receptor tyrosine kinase, is widely expressed in many cell types within fetal and postnatal tissues, and in many cell lines. Upon binding to its ligands, IGF-I and IGF-II, receptor autophosphorylation occurs. The triple tyrosine cluster within the kinase domain (Tyr1131, Tyr1135 and Tyr1136) is the earliest major site of autophosphorylation. Phosphorylation of these three tyrosine residues is necessary for kinase activation.Insulin receptors (IRs) share significant similarity with IGF1 receptors in both structure and function,including an equivalent triple tyrosine cluster within the activation loop of the kinase domain (Tyr1146, Tyr1150 and Tyr1151).Tyrosine autophosphorylation of insulin receptor is one of the earliest cellular responses to insulin stimulation. Autophosphorylation begins with phosphorylation of Tyr1146 and either Tyr1150 or Tyr1151. Full kinase activation requires the triple tyrosine phosphorylation.
Pathways Signalisation RTK, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Autophagy
Indications d'application Western Blot: 1: 500- 1: 2,000
IHC(P): 1: 500- 1: 2,000
IHC(F): 1: 500- 1: 2,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Stock -20 °C
Produit citée dans: Scheidegger, Cenni, Picard, Delafontaine: "Estradiol decreases IGF-1 and IGF-1 receptor expression in rat aortic smooth muscle cells. Mechanisms for its atheroprotective effects." dans: The Journal of biological chemistry, Vol. 275, Issue 49, pp. 38921-8, 2001 (PubMed).

Fujimoto, Tomita, Wakamatsu, Tanimoto, Ike: "Physical mapping of the conjugative bacteriocin plasmid pPD1 of Enterococcus faecalis and identification of the determinant related to the pheromone response." dans: Journal of bacteriology, Vol. 177, Issue 19, pp. 5574-81, 1995 (PubMed).

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