LKB1 anticorps (C-Term)

N° du produit ABIN966488

Il existe 1 publication pour ce produit. L’anticorps anti-LKB1 Polyclonal Lapin est utilisé pour la détection de LKB1 dans des échantillons de Humain. Il a été validé pour WB et IHC (p).

Aperçu rapide pour LKB1 anticorps (C-Term) (ABIN966488)

Antigène: LKB1 (STK11) (serine/threonine Kinase 11 (STK11))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LKB1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-LKB1 anticorps

Épitope: C-Term

Réactivité croisée: Souris, Rat (Rattus)

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for Serine/threonine-protein kinase STK11 (STK11) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminal of human STK11, different from the mouse sequence by one amino acid.< br/>Immunogen was affinity purified.

Isotype: IgG

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide, Thimerosal (Merthiolate)

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.

Références pour anticorps anti-LKB1 (ABIN966488)

Jenne, Reimann, Nezu, Friedel, Loff, Jeschke, Müller, Back, Zimmer: "Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase." dans: Nature genetics, Vol. 18, Issue 1, pp. 38-43, (1998) (PubMed).

Détails sur LKB1

Antigène: LKB1 (STK11) (serine/threonine Kinase 11 (STK11))

Autre désignation: Serine/threonine-protein kinase STK11

Sujet: Serine/threonine kinase 11 or LKB1 is a protein kinase which in humans is encoded by the STK11 gene. The STK11/LKB1 gene, which encodes a member of the serine/threonine kinase, regulates cell polarity and functions as a tumour suppressor Smith et al. (1999) found that the mouse Lkb1 gene encodes a protein showing strong sequence similarity to human LKB1. Karuman et al. (2001) demonstrated that LKB1 physically associates with p53 (191170) and regulates specific p53-dependent apoptosis pathways. Jenne et al. (1998) determined that the STK11 gene extends over 23 kb of genomic DNA and is composed of 9 exons, which are transcribed in telomere-to-centromere direction. Smith et al. (1999) found that the mouse Lkb1 gene consists of 10 exons covering approximately 15 kb.

Pathways: AMPK Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, L'effet Warburg