NOTCH3 anticorps (Notch 3) (C-Term)

Details for Product anti-NOTCH3 Antibody No. ABIN966682, Fournisseur: Connectez-vous pour afficher
Antigène
  • CADASIL
  • CASIL
  • IMF2
  • AW229011
  • N3
  • hpbk
  • fa14b08
  • notch5
  • wu:fa14b08
  • notch 3
  • NOTCH3
  • Notch3
  • notch3
Épitope
C-Term
53
18
16
12
7
7
7
7
5
4
3
2
2
2
2
1
1
1
1
Reactivité
Humain
188
47
31
6
2
1
Hôte
Lapin
101
65
23
13
3
2
1
Clonalité
Polyclonal
Conjugué
Cet anticorp NOTCH3 est non-conjugé
16
13
7
7
7
6
4
4
4
4
4
2
2
2
2
2
2
2
2
2
2
2
Application
Immunohistochemistry (IHC)
115
109
92
82
13
9
7
4
4
4
3
3
1
1
1
Options
Fournisseur
Connectez-vous pour afficher
N° du produit (Fournisseur)
Connectez-vous pour afficher
Immunogène Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human NOTCH3 (Neurogenic locus notch homolog protein 3)
Plasmids, Primers & others Plasmids, Primers & others NOTCH3 products on genomics-online (e.g. as negative or positive controls)
Autre désignation NOTCH3 (NOTCH3 Antibody Extrait)
Sujet NOTCH3 (Neurogenic locus notch homolog protein 3) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. NOTCH3 affects the implementation of differentiation, proliferation and apoptotic programs. NOTCH3 is a heterodimer of a C-terminal fragment N(TM) and a N-terminal fragment N(EC) which are probably linked by disulfide bonds. NOTCH3 interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH3. NOTCH3 is ubiquitously expressed in fetal and adult tissues. It is synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane. Defects in NOTCH3 are the cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). CADASIL causes a type of stroke and dementia of which key features include recurrent subcortical ischemic events and vascular dementia. The disorder affects relatively young adults of both sexes.
Pathways Signalisation Notch
Restrictions For Research Use only
Produit citée dans: Wu, Sun, Kobayashi, Gao, Griffin: "Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors." dans: Molecular and cellular biology, Vol. 22, Issue 21, pp. 7688-700, 2002 (PubMed).

Gray, Mann, Mitsiadis, Henrique, Carcangiu, Banks, Leiman, Ward, Ish-Horowitz, Artavanis-Tsakonas: "Human ligands of the Notch receptor." dans: The American journal of pathology, Vol. 154, Issue 3, pp. 785-94, 1999 (PubMed).

Joutel, Corpechot, Ducros, Vahedi, Chabriat, Mouton, Alamowitch, Domenga, Cécillion, Marechal, Maciazek, Vayssiere, Cruaud, Cabanis, Ruchoux, Weissenbach, Bach, Bousser, Tournier-Lasserve: "Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia." dans: Nature, Vol. 383, Issue 6602, pp. 707-10, 1996 (PubMed).

Avez-vous cherché autre chose?