POLB anticorps (Polymerase (DNA Directed), beta) (N-Term)

Details for Product anti-POLB Antibody No. ABIN966879, Fournisseur: Connectez-vous pour afficher
Antigène
  • wu:fa97a05
  • zgc:109924
  • POLB
  • DDBDRAFT_0186152
  • DDBDRAFT_0215784
  • DDBDRAFT_0232376
  • DDB_0186152
  • DDB_0215784
  • DDB_0232376
  • A430088C08Rik
  • polymerase (DNA directed), beta
  • DNA polymerase beta
  • DNA polymerase X family protein
  • polymerase (DNA directed), beta S homeolog
  • polb
  • POLB
  • polB
  • polb.S
  • Polb
Épitope
N-Term, 2meArg83
15
11
5
4
4
3
2
2
2
2
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
94
54
51
9
6
4
3
2
2
2
2
2
2
1
1
1
Hôte
Lapin
73
25
Clonalité
Polyclonal
Conjugué
Cet anticorp POLB est non-conjugé
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC)
78
45
24
20
13
10
8
2
1
1
Options
Fournisseur
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N° du produit (Fournisseur)
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Immunogène Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human POLB (DNA polymerase beta)
Autre désignation POLB (POLB Antibody Extrait)
Sujet POLB (DNA polymerase beta) is a repair polymerase. POLB conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. POLB has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. POLB binds 2 magnesium ions per subunit (By similarity).POLB belongs to the DNA polymerase type-X family.
Pathways Réparation de l'ADN
Restrictions For Research Use only
Produit citée dans: El-Andaloussi, Valovka, Toueille, Steinacher, Focke, Gehrig, Covic, Hassa, Schär, Hübscher, Hottiger: "Arginine methylation regulates DNA polymerase beta." dans: Molecular cell, Vol. 22, Issue 1, pp. 51-62, 2006 (PubMed).

DeMott, Beyret, Wong, Bales, Hwang, Greenberg, Demple: "Covalent trapping of human DNA polymerase beta by the oxidative DNA lesion 2-deoxyribonolactone." dans: The Journal of biological chemistry, Vol. 277, Issue 10, pp. 7637-40, 2002 (PubMed).

Patterson, Little, Cheng, Widen, Kumar, Beard, Wilson: "Molecular cloning and high-level expression of human polymerase beta cDNA and comparison of the purified recombinant human and rat enzymes." dans: Protein expression and purification, Vol. 18, Issue 1, pp. 100-10, 2000 (PubMed).

Matsumoto, Kim, Katz, Feng: "Catalytic center of DNA polymerase beta for excision of deoxyribose phosphate groups." dans: Biochemistry, Vol. 37, Issue 18, pp. 6456-64, 1998 (PubMed).

Dobashi, Kubota, Shuin, Torigoe, Yao, Hosaka: "Polymorphisms in the human DNA polymerase beta gene." dans: Human genetics, Vol. 95, Issue 4, pp. 389-90, 1995 (PubMed).

Chyan, Ackerman, Shepherd, McBride, Widen, Wilson, Wood: "The human DNA polymerase beta gene structure. Evidence of alternative splicing in gene expression." dans: Nucleic acids research, Vol. 22, Issue 14, pp. 2719-25, 1994 (PubMed).

Widen, Kedar, Wilson: "Human beta-polymerase gene. Structure of the 5'-flanking region and active promoter." dans: The Journal of biological chemistry, Vol. 263, Issue 32, pp. 16992-8, 1988 (PubMed).

Abbotts, SenGupta, Zmudzka, Widen, Notario, Wilson: "Expression of human DNA polymerase beta in Escherichia coli and characterization of the recombinant enzyme." dans: Biochemistry, Vol. 27, Issue 3, pp. 901-9, 1988 (PubMed).

SenGupta, Zmudzka, Kumar, Cobianchi, Skowronski, Wilson: "Sequence of human DNA polymerase beta mRNA obtained through cDNA cloning." dans: Biochemical and biophysical research communications, Vol. 136, Issue 1, pp. 341-7, 1986 (PubMed).

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