SasG Gene Product (SASG) (C-Term) anticorps

Détails pour le produit réf. ABIN966995, Fournisseur: Connectez-vous pour afficher
Antigène
Épitope
C-Term
Reactivité
Staphylococcus aureus (S. aureus)
Hôte
Lapin
Clonalité
Polyclonal
Application
Immunohistochemistry (IHC)
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Immunogène Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of Bacteria: Staphylococcus aureus SasG (Surface protein G)
Autre désignation SasG
Sujet SasG (Surface protein G) promotes adhesion of bacterial cells to human squamous nasal epithelial cells, a phenomenon which is likely to be important in nasal colonization. Forms short, extremely dense and thin fibrils all over the bacterial surface. SasG (Surface protein G) does not bind to either buccal cells or non-differentiated keratinocytes. SasG (Surface protein G) promotes cellular aggregation leading to biofilm formation. SasG (Surface protein G) is secreted, cell wall protein. It is produced during infection of the human host. SasG (Surface protein G) does not bind to immobilized fibrinogen, fibronectin, IgG, human epidermal keratin, collagen, vWF, laminin, heparan sulfate and submaxillary mucin. When sasG is expressed at high levels, it inhibits adhesion of S.aureus to the ligands fibrinogen, fibronectin, cytokeratin 10 and IgG. This inhibitory effect depends on the number of G5 repeats present in the protein, since shorter variants do not present this phenotype. Biofilm formation is ica-independent, relying only on the level of expression of the protein and the number of G5 repeats.
Restrictions For Research Use only
Background publications Corrigan, Rigby, Handley, Foster: "The role of Staphylococcus aureus surface protein SasG in adherence and biofilm formation." dans: Microbiology (Reading, England), Vol. 153, Issue Pt 8, pp. 2435-46, 2007 (PubMed).

Roche, Massey, Peacock, Day, Visai, Speziale, Lam, Pallen, Foster: "Characterization of novel LPXTG-containing proteins of Staphylococcus aureus identified from genome sequences." dans: Microbiology (Reading, England), Vol. 149, Issue Pt 3, pp. 643-54, 2003 (PubMed).

Roche, Meehan, Foster: "The Staphylococcus aureus surface protein SasG and its homologues promote bacterial adherence to human desquamated nasal epithelial cells." dans: Microbiology (Reading, England), Vol. 149, Issue Pt 10, pp. 2759-67, 2003 (PubMed).

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