SLC4A11 anticorps (C-Term)

N° du produit ABIN967035

Détail du produit anti-SLC4A11 anticorps

Antigène: SLC4A11 (Solute Carrier Family 4, Sodium Borate Transporter, Member 11 (SLC4A11))

Épitope: C-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SLC4A11 est non-conjugé

Application: Immunohistochemistry (IHC)

Immunogène: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human SLC4A11 (Sodium bicarbonate transporter-like protein 11)

Information d'application

Restrictions: For Research Use only

Stockage

Stock: 4 °C

Références pour anticorps anti-SLC4A11 (ABIN967035)

Vithana, Morgan, Ramprasad, Tan, Yong, Venkataraman, Venkatraman, Yam, Nagasamy, Law, Rajagopal, Pang, Kumaramanickevel, Casey, Aung: "SLC4A11 mutations in Fuchs endothelial corneal dystrophy." dans: Human molecular genetics, Vol. 17, Issue 5, pp. 656-66, (2008) (PubMed).

Jiao, Sultana, Garg, Ramamurthy, Vemuganti, Gangopadhyay, Hejtmancik, Kannabiran: "Autosomal recessive corneal endothelial dystrophy (CHED2) is associated with mutations in SLC4A11." dans: Journal of medical genetics, Vol. 44, Issue 1, pp. 64-8, (2007) (PubMed).

Desir, Moya, Reish, Van Regemorter, Deconinck, David, Meire, Abramowicz: "Borate transporter SLC4A11 mutations cause both Harboyan syndrome and non-syndromic corneal endothelial dystrophy." dans: Journal of medical genetics, Vol. 44, Issue 5, pp. 322-6, (2007) (PubMed).

Vithana, Morgan, Sundaresan, Ebenezer, Tan, Mohamed, Anand, Khine, Venkataraman, Yong, Salto-Tellez, Venkatraman, Guo, Hemadevi, Srinivasan, Prajna, Khine, Casey, Inglehearn, Aung: "Mutations in sodium-borate cotransporter SLC4A11 cause recessive congenital hereditary endothelial dystrophy (CHED2)." dans: Nature genetics, Vol. 38, Issue 7, pp. 755-7, (2006) (PubMed).

Park, Li, Shcheynikov, Zeng, Muallem: "NaBC1 is a ubiquitous electrogenic Na+ -coupled borate transporter essential for cellular boron homeostasis and cell growth and proliferation." dans: Molecular cell, Vol. 16, Issue 3, pp. 331-41, (2004) (PubMed).

Parker, Ourmozdi, Tanner: "Human BTR1, a new bicarbonate transporter superfamily member and human AE4 from kidney." dans: Biochemical and biophysical research communications, Vol. 282, Issue 5, pp. 1103-9, (2001) (PubMed).

Détails sur SLC4A11

Antigène: SLC4A11 (Solute Carrier Family 4, Sodium Borate Transporter, Member 11 (SLC4A11))

Autre désignation: SLC4A11 (SLC4A11 Produits)

Synonymes: anticorps NaBC1, anticorps si:dkey-12j14.4, anticorps AI503023, anticorps BTR1, anticorps CDPD1, anticorps CHED2, anticorps NABC1, anticorps dJ794I6.2, anticorps solute carrier family 4 member 11, anticorps solute carrier family 4 member 11 L homeolog, anticorps solute carrier family 4, sodium borate transporter, member 11, anticorps solute carrier family 4, sodium bicarbonate transporter-like, member 11, anticorps Slc4a11, anticorps SLC4A11, anticorps slc4a11.L, anticorps slc4a11

Sujet: SLC4A11 (Sodium bicarbonate transporter-like protein 11) involved in borate homeostasis. In the absence of borate, it functions as a Na(+) and OH(-)(H(+)) channel. In the presence of borate functions as an electrogenic Na(+) coupled borate cotransporter. SLC4A11 (Sodium bicarbonate transporter-like protein 11) is a multi-pass membrane protein. SLC4A11 is highly expressed in kidney, testis, salivary gland, thyroid, trachea and corneal endothelium. Defects in SLC4A11 are the cause of corneal dystrophy and perceptive deafness (CDPD), also known as corneal dystrophy and sensorineural deafness or Harboyan syndrome. CDPD consists of congenital corneal endothelial dystrophy and progressive perceptive deafness. Inheritance is autosomal recessive. Defects in SLC4A11 are the cause of corneal endothelial dystrophy type 2 (CHED2) [MIM:217700], also known as congenital hereditary endothelial dystrophy of cornea. This bilateral corneal dystrophy is characterized by corneal opacification and nystagmus. Inheritance is autosomal recessive.

Pathways: Proton Transport