IGF1R anticorps

N° du produit ABIN967487

Détail du produit anti-IGF1R anticorps

Antigène: IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IGF1R est non-conjugé

Application: Flow Cytometry (FACS), Fluorescence Microscopy (FM)

Marque: BD Pharmingen™

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Clone: 1H7

Isotype: IgG1 kappa

Information d'application

Indications d'application: This product is routinely tested on peripheral blood granulocytes. The histogram is an example of the expected reactivity.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4° C.

Références pour anticorps anti-IGF1R (ABIN967487)

Kooijman, Scholtens, Rijkers, Zegers: "Differential expression of type I insulin-like growth factor receptors in different stages of human T cells." dans: European journal of immunology, Vol. 25, Issue 4, pp. 931-5, (1995) (PubMed).

Li, Kato, Paz, Kasuya, Fujita-Yamaguchi: "Two new monoclonal antibodies against the alpha subunit of the human insulin-like growth factor-I receptor." dans: Biochemical and biophysical research communications, Vol. 196, Issue 1, pp. 92-8, (1993) (PubMed).

Xiong, Kasuya, Li, Kato, Fujita-Yamaguchi: "Growth-stimulatory monoclonal antibodies against human insulin-like growth factor I receptor." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 12, pp. 5356-60, (1992) (PubMed).

Détails sur IGF1R

Antigène: IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

Autre désignation: CD221 (IGF1R Produits)

Synonymes: anticorps CMT2N, anticorps CD221, anticorps IGFIR, anticorps IGFR, anticorps JTK13, anticorps IGFIRC, anticorps IGFR1, anticorps IGF-1R, anticorps IGF1R, anticorps DKFZp469I0618, anticorps igf-1r, anticorps xIGF-1R, anticorps xIGFR, anticorps xigf1r, anticorps A330103N21Rik, anticorps D930020L01, anticorps hyft, anticorps igf-ir, anticorps IGF-IR, anticorps IGF-IRb, anticorps wu:fb03h06, anticorps IGF-IRa, anticorps sb:eu1090, anticorps wu:fi20b10, anticorps alanyl-tRNA synthetase, anticorps insulin like growth factor 1 receptor, anticorps insulin-like growth factor 1 receptor, anticorps insulin-like growth factor 1, anticorps insulin-like growth factor I receptor, anticorps insulin like growth factor 1 receptor S homeolog, anticorps insulin-like growth factor 1b receptor, anticorps insulin-like growth factor 1a receptor, anticorps AARS, anticorps IGF1R, anticorps Igf1r, anticorps igf1r, anticorps Igf1, anticorps LOC780503, anticorps LOC100136427, anticorps igf1r.S, anticorps igf1rb, anticorps igf1ra

Sujet: Reacts with human insulin-like growth factor-I (IGF-I) receptor alpha subunit (135 kDa). IGF-IRalpha is a glycoprotein complex composed of two extracellular alpha subunits and two transmembrane beta subunits. The transmembrane subunits play a role in tyrosine phosphorylation of several intracellular signaling proteins. IGF-IRalpha is structurally and functionally similar to insulin receptor and is expressed on a variety of human hematopoietic and non-hematopoietic cells. It mediates the effects of IGF-I and IGF-II on cellular growth. 1H7 does not cross react with human insulin receptor and it can block IGF-I or IGF-II stimulated cell growth. This antibody is routinely tested by flow cytometric analysis.
Synonyms: IGF-I Receptor alpha

Pathways: Signalisation RTK, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Autophagy