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Paxillin anticorps (AA 1-557)

PXN Reactivité: Humain, Souris, Rat, Poulet, Chien WB, IF, IP, IHC (f) Hôte: Souris Monoclonal 349-Paxillin unconjugated
N° du produit ABIN967711
  • Antigène Voir toutes Paxillin (PXN) Anticorps
    Paxillin (PXN)
    Épitope
    • 32
    • 26
    • 17
    • 16
    • 11
    • 9
    • 8
    • 7
    • 7
    • 7
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-557
    Reactivité
    • 205
    • 110
    • 78
    • 22
    • 10
    • 9
    • 8
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Poulet, Chien
    Hôte
    • 191
    • 33
    • 1
    Souris
    Clonalité
    • 176
    • 49
    Monoclonal
    Conjugué
    • 128
    • 10
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 6
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    Cet anticorp Paxillin est non-conjugé
    Application
    • 173
    • 67
    • 41
    • 41
    • 40
    • 32
    • 27
    • 25
    • 24
    • 14
    • 14
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
     Réactivité croisée
    Humain, Chien, Souris, Rat (Rattus)
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Chicken Paxillin aa. 1-557
    Clone
    349-Paxillin
    Isotype
    IgG1
    Top Product
    Discover our top product PXN Anticorps primaire
  • Commentaires

    Related Products: ABIN968533, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20° C.
  • Even-Ram, Maoz, Pokroy, Reich, Katz, Gutwein, Altevogt, Bar-Shavit: "Tumor cell invasion is promoted by activation of protease activated receptor-1 in cooperation with the alpha vbeta 5 integrin." dans: The Journal of biological chemistry, Vol. 276, Issue 14, pp. 10952-62, (2001) (PubMed).

    Nikolopoulos, Turner: "Actopaxin, a new focal adhesion protein that binds paxillin LD motifs and actin and regulates cell adhesion." dans: The Journal of cell biology, Vol. 151, Issue 7, pp. 1435-48, (2001) (PubMed).

    van de Water, Houtepen, Huigsloot, Tijdens: "Suppression of chemically induced apoptosis but not necrosis of renal proximal tubular epithelial (LLC-PK1) cells by focal adhesion kinase (FAK). Role of FAK in maintaining focal adhesion organization after acute renal cell injury." dans: The Journal of biological chemistry, Vol. 276, Issue 39, pp. 36183-93, (2001) (PubMed).

    Wine, Chapin: "Adhesion and signaling proteins spatiotemporally associated with spermiation in the rat." dans: Journal of andrology, Vol. 20, Issue 2, pp. 198-213, (1999) (PubMed).

  • Antigène
    Paxillin (PXN)
    Autre désignation
    Paxillin (PXN Produits)
    Synonymes
    anticorps AW108311, anticorps AW123232, anticorps Pax, anticorps CG18061, anticorps CG18576, anticorps CG31794, anticorps CT40481, anticorps CT42454, anticorps DPaxillin, anticorps DPxn, anticorps DPxn37, anticorps Dmel\\CG31794, anticorps Dpax, anticorps DpaxA, anticorps PDLP, anticorps dPax, anticorps pax, anticorps wu:fw71f12, anticorps PXN, anticorps LOC100220858, anticorps paxillin, anticorps Paxillin, anticorps paxillin S homeolog, anticorps paxillin a, anticorps PXN, anticorps Pxn, anticorps Pax, anticorps pxn.S, anticorps pxna, anticorps LOC696336, anticorps pxn
    Sujet
    A number of cytoskeletal proteins are tyrosine phosphorylated in Rous sarcoma virus-transformed chick embryo fibroblasts. One of these is the 68 kDa paxillin protein. Paxillin is a cytoskeletal component that localizes to the focal adhesions at the ends of actin stress fibers. It is also present in the focal adhesions of Madin-Darby canine kidney epithelial cells, but is absent from the cell adherens junctions of these cells. Paxillin purified from chicken gizzard migrates as a diffuse band on SDS-PAGE with molecular weight of 65-70 kDa. It binds to the rod domain of vinculin, another focal adhesion protein. It is thought that phosphorylation of paxillin may have a role in that disassembly of focal adhesions and stress fibers during transformation. This antibody is routinely tested by Western blot analysis.
    Poids moléculaire
    68 kDa
    Pathways
    Signalisation MAPK, EGFR Signaling Pathway, Response to Growth Hormone Stimulus, Cell-Cell Junction Organization, Maintenance of Protein Location, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling
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