ITGB1 anticorps (AA 76-256)

N° du produit ABIN967992

Cet anticorps anti-ITGB1 est un anticorps Souris Monoclonal détectant ITGB1 dans WB, IP, IF et IHC (f). Adapté pour Humain, Souris, Rat, Chien et Poulet. Ce Primary Antibody a été cité dans 5+ publications.

Aperçu rapide pour ITGB1 anticorps (AA 76-256) (ABIN967992)

Antigène: ITGB1 (Integrin beta 1 (ITGB1))

Reactivité: Humain, Souris, Rat, Chien, Poulet

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ITGB1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Clone: 18-CD29

Détail du produit anti-ITGB1 anticorps

Épitope: AA 76-256

Réactivité croisée: Chien, Rat (Rattus), Souris, Poulet

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human CD29 aa. 76-256

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN967389, ABIN968533

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20° C.

Références pour anticorps anti-ITGB1 (ABIN967992)

Ivaska, Whelan, Watson, Parker: "PKC epsilon controls the traffic of beta1 integrins in motile cells." dans: The EMBO journal, Vol. 21, Issue 14, pp. 3608-19, (2002) (PubMed).

Tang, Hao, Fitzgerald, Sasaki, Landon, Inagami: "Pyk2/CAKbeta tyrosine kinase activity-mediated angiogenesis of pulmonary vascular endothelial cells." dans: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 5441-7, (2002) (PubMed).

Huan, van Adelsberg: "Polycystin-1, the PKD1 gene product, is in a complex containing E-cadherin and the catenins." dans: The Journal of clinical investigation, Vol. 104, Issue 10, pp. 1459-68, (1999) (PubMed).

Yeh, Peng, Huang: "Accutin, a new disintegrin, inhibits angiogenesis in vitro and in vivo by acting as integrin alphavbeta3 antagonist and inducing apoptosis." dans: Blood, Vol. 92, Issue 9, pp. 3268-76, (1998) (PubMed).

Cervella, Silengo, Pastore, Altruda: "Human beta 1-integrin gene expression is regulated by two promoter regions." dans: The Journal of biological chemistry, Vol. 268, Issue 7, pp. 5148-55, (1993) (PubMed).

Détails sur ITGB1

Antigène: ITGB1 (Integrin beta 1 (ITGB1))

Autre désignation: CD29

Sujet: Integrins are membrane receptors that mediate cell-cell or cell-matrix adhesion. All integrins are transmembrane heterodimers composed of alpha and beta subunits and are connected to the cytoskeleton. At least 20 integrins, formed from combinations of 12 alpha and 9 beta subunits, have been reported. Many of these have been implicated as transducers of molecular signals. The beta1 subgroup of this receptor family comprises at least six different dimer combinations. Among these combinations, alpha2beta1 is associated with type I collagen and laminin binding and regulation, alpha3beta1 is a receptor for laminin and epiligrin, and alpha5beta1 is a fibronectin receptor. beta1 integrins play an important role in several aspects of epidermal differentiation and morphogenesis. Expression of the beta1 subunit is regulated by growth factors such as TGF-beta1. Integrin activation, which enhances binding of T cells to endothelium, is regulated in part by phosphatidylinositol 3-kinase. Focal adhesion kinase (FAK) and paxillin have been reported to independently bind the C-terminal, cytoplasmic domain of the beta1 subunit. FAK is reported to be enzymatically activated upon engagement of integrins with their ligands and paxillin is phosphorylated on tyrosine upon activation of FAK.
Synonyms: Integrin beta1, platelet GPIIa, VLA beta-chain

Poids moléculaire: 130 kDa

Pathways: Cell-Cell Junction Organization, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor, Integrin Complex, SARS-CoV-2 Protein Interactome