Paxillin anticorps (AA 1-557)

N° du produit ABIN968067

Cet anticorps anti-Paxillin est un anticorps Souris Monoclonal détectant Paxillin dans WB, IHC, IP et IF. Adapté pour Humain, Souris, Rat, Poulet et Chien. Ce Primary Antibody a été cité dans 5+ publications.

Aperçu rapide pour Paxillin anticorps (AA 1-557) (ABIN968067)

Antigène: Paxillin (PXN)

Reactivité: Humain, Souris, Rat, Poulet, Chien

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Paxillin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Clone: 165-Paxillin

Détail du produit anti-Paxillin anticorps

Épitope: AA 1-557

Réactivité croisée: Humain, Chien, Rat (Rattus), Souris

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Chicken Paxillin aa. 1-557

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968536, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20° C.

Références pour anticorps anti-Paxillin (ABIN968067)

Laukaitis, Webb, Donais, Horwitz: "Differential dynamics of alpha 5 integrin, paxillin, and alpha-actinin during formation and disassembly of adhesions in migrating cells." dans: The Journal of cell biology, Vol. 153, Issue 7, pp. 1427-40, (2001) (PubMed).

Müller, Jung, Wied, Welte, Jordan, Frick: "Redistribution of glycolipid raft domain components induces insulin-mimetic signaling in rat adipocytes." dans: Molecular and cellular biology, Vol. 21, Issue 14, pp. 4553-67, (2001) (PubMed).

Herreros, Rodríguez-Fernandez, Brown, Alonso-Lebrero, Cabañas, Sánchez-Madrid, Longo, Turner, Sánchez-Mateos: "Paxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeleton." dans: The Journal of biological chemistry, Vol. 275, Issue 34, pp. 26436-40, (2000) (PubMed).

Salgia, Li, Lo, Brunkhorst, Kansas, Sobhany, Sun, Pisick, Hallek, Ernst: "Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL." dans: The Journal of biological chemistry, Vol. 270, Issue 10, pp. 5039-47, (1995) (PubMed).

Turner, Glenney, Burridge: "Paxillin: a new vinculin-binding protein present in focal adhesions." dans: The Journal of cell biology, Vol. 111, Issue 3, pp. 1059-68, (1990) (PubMed).

Détails sur Paxillin

Antigène: Paxillin (PXN)

Autre désignation: Paxillin

Sujet: Paxillin, a focal adhesion protein, is a substrate for several tyrosine kinases such as src, FAK, and p120BRC/ABL. The tyrosine phosphorylation of paxillin is affected by conditions that change cell-cell adhesion. This is consisent with the possibility that paxillin is involved in the regulation of cell morphology. Additionally, because of its SH3 binding domain, paxillin associates tightly with FAK and Crk in an extracellular matrix-independent manner. Paxillin was initially detected in fibroblasts, and its phosphorylation may be important during neurite extension during differentiation. This antibody is routinely tested by western blot analysis.

Poids moléculaire: 68 kDa

Pathways: Signalisation MAPK, EGFR Signaling Pathway, Response to Growth Hormone Stimulus, Cell-Cell Junction Organization, Maintenance of Protein Location, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling