RABEP1 anticorps (AA 247-417)

N° du produit ABIN968104

Détail du produit anti-RABEP1 anticorps

Antigène: RABEP1 (Rabaptin, RAB GTPase Binding Effector Protein 1 (RABEP1))

Épitope: AA 247-417

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp RABEP1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Réactivité croisée: Souris, Rat (Rattus)

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human Rabaptin-5 aa. 247-417.

Clone: 20-Rabaptin

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968585, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20° C.

Références pour anticorps anti-RABEP1 (ABIN968104)

Shiba, Takatsu, Shin, Nakayama: "Gamma-adaptin interacts directly with Rabaptin-5 through its ear domain." dans: Journal of biochemistry, Vol. 131, Issue 3, pp. 327-36, (2002) (PubMed).

Zhu, Doray, Poussu, Lehto, Kornfeld: "Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor." dans: Science (New York, N.Y.), Vol. 292, Issue 5522, pp. 1716-8, (2001) (PubMed).

Stenmark, Vitale, Ullrich, Zerial: "Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion." dans: Cell, Vol. 83, Issue 3, pp. 423-32, (1996) (PubMed).

Détails sur RABEP1

Antigène: RABEP1 (Rabaptin, RAB GTPase Binding Effector Protein 1 (RABEP1))

Autre désignation: Rabaptin-5 (RABEP1 Produits)

Synonymes: anticorps RAB5EP, anticorps RABPT5, anticorps AA409789, anticorps AI481320, anticorps AV213537, anticorps AW240603, anticorps Rab5ep, anticorps rabaptin-5, anticorps rabaptin, RAB GTPase binding effector protein 1, anticorps RABEP1, anticorps Rabep1

Sujet: Rabs are small GTP-binding proteins that are localized to specific intracellular vesicles and organelles. They are important for the regulation of vesicular traffic. It is thought that Rabs cycle between GTP- and GDP-bound forms and this cycle is related to their function. Rabaptin-5 is protein that interacts with GTP-Rab5. Although Rabaptin-5 is localized in the cytosol, it is also recruited to the endosomal fraction in a Rab5 and GTP-dependent manner. The removal of Rabaptin-5 from the cytosol substantially impairs GTP and Rab5-dependent endosomal fusion. This indicates that Rabaptin-5 may be an important partner of Rab5 during endocytosis. Rabaptin-5 contains 862 amino acids and both ends of the protein contain coiled-coil domains typically found in vesicular transport proteins. This antibody is routinely tested by western blot analysis.

Poids moléculaire: 117 kDa