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RAD9A anticorps (AA 264-370)

RAD9A Reactivité: Humain, Souris, Rat WB, IF Hôte: Souris Monoclonal 56-hRad9 unconjugated
N° du produit ABIN968473
  • Antigène Voir toutes RAD9A Anticorps
    RAD9A (RAD9 Homolog A (S. Pombe) (RAD9A))
    Épitope
    • 22
    • 15
    • 15
    • 10
    • 8
    • 8
    • 8
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 264-370
    Reactivité
    • 135
    • 48
    • 21
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 148
    • 8
    • 1
    Souris
    Clonalité
    • 149
    • 8
    Monoclonal
    Conjugué
    • 67
    • 15
    • 13
    • 12
    • 11
    • 11
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp RAD9A est non-conjugé
    Application
    • 137
    • 86
    • 57
    • 28
    • 27
    • 26
    • 13
    • 9
    • 8
    • 7
    • 7
    • 6
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
     Réactivité croisée
    Souris, Rat (Rattus)
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Human hRAD9 aa. 264-370
    Clone
    56-hRad9
    Isotype
    IgG1
    Top Product
    Discover our top product RAD9A Anticorps primaire
  • Commentaires

    Related Products: ABIN968536, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20° C.
  • Yoshida, Komatsu, Wang, Kufe: "c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage." dans: Molecular and cellular biology, Vol. 22, Issue 10, pp. 3292-300, (2002) (PubMed).

    Komatsu, Miyashita, Hang, Hopkins, Zheng, Cuddeback, Yamada, Lieberman, Wang: "Human homologue of S. pombe Rad9 interacts with BCL-2/BCL-xL and promotes apoptosis." dans: Nature cell biology, Vol. 2, Issue 1, pp. 1-6, (2000) (PubMed).

    Volkmer, Karnitz: "Human homologs of Schizosaccharomyces pombe rad1, hus1, and rad9 form a DNA damage-responsive protein complex." dans: The Journal of biological chemistry, Vol. 274, Issue 2, pp. 567-70, (1999) (PubMed).

    St Onge, Udell, Casselman, Davey: "The human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1." dans: Molecular biology of the cell, Vol. 10, Issue 6, pp. 1985-95, (1999) (PubMed).

    Lieberman, Hopkins, Nass, Demetrick, Davey: "A human homolog of the Schizosaccharomyces pombe rad9+ checkpoint control gene." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 24, pp. 13890-5, (1997) (PubMed).

  • Antigène
    RAD9A (RAD9 Homolog A (S. Pombe) (RAD9A))
    Autre désignation
    hRad9 (RAD9A Produits)
    Synonymes
    anticorps RAD9, anticorps Rad9, anticorps rad9a, anticorps MGC89062, anticorps XRad9, anticorps rad9, anticorps RAD9 checkpoint clamp component A, anticorps RAD9 checkpoint clamp component B, anticorps RAD9 checkpoint clamp component A L homeolog, anticorps RAD9A, anticorps Rad9a, anticorps rad9a, anticorps rad9b, anticorps rad9a.L
    Sujet
    Cell cycle checkpoints are regulatory mechanisms that prevent cell cycle progression in the presence of DNA damage or incompletely replicated DNA. Many of the genes required for cell-cycle arrest are also involved in DNA repair, apoptosis, and induction of transcription. In yeast and humans, hRAD9 plays a role in cell cycle arrest during the G2 phase before entry into mitosis. Phosphorylated hRAD9 is found in the nucleus after DNA damage, and forms DNA damage-responsive complexes with other putative checkpoint control proteins, such as hRAD1 and hHUS1. Expression of hRAD9 in S. pombe rad9::ura4+ cells restores resistance to the DNA synthesis inhibitor hydroxyurea and gamma rays. In addition, hRAD9 binds the anti-apoptotic proteins, Bcl-2 and Bcl-xL , and antisense hRAD9 RNA suppresses DNA-damage induced cell death. Thus, hRAD9 may be an important component of protein complexes that regulate cell cycle progression, as well as apoptosis, in response to DNA damage.
    Poids moléculaire
    60 kDa
    Pathways
    Positive Regulation of Response to DNA Damage Stimulus
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