CNKSR1 anticorps (AA 10-217)

N° du produit ABIN968649

Détail du produit anti-CNKSR1 anticorps

Antigène: CNKSR1 (Connector Enhancer of Kinase Suppressor of Ras 1 (CNKSR1))

Épitope: AA 10-217

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CNKSR1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human hCNK1 aa. 10-217

Clone: 46-hCNK1

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968533, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20° C.

Références pour anticorps anti-CNKSR1 (ABIN968649)

Therrien, Wong, Kwan, Rubin: "Functional analysis of CNK in RAS signaling." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 23, pp. 13259-63, (1999) (PubMed).

Therrien, Wong, Rubin: "CNK, a RAF-binding multidomain protein required for RAS signaling." dans: Cell, Vol. 95, Issue 3, pp. 343-53, (1998) (PubMed).

Détails sur CNKSR1

Antigène: CNKSR1 (Connector Enhancer of Kinase Suppressor of Ras 1 (CNKSR1))

Autre désignation: hCNK1 (CNKSR1 Produits)

Synonymes: anticorps zgc:77200, anticorps CNKSR1, anticorps cnk, anticorps ksr, anticorps cnk1, anticorps CNK, anticorps CNK1, anticorps KSR, anticorps BC037758, anticorps connector enhancer of kinase suppressor of Ras 1, anticorps connector enhancer of kinase suppressor of Ras 1 L homeolog, anticorps cnksr1, anticorps CNKSR1, anticorps cnksr1.L, anticorps Cnksr1

Sujet: Proteins of the Ras superfamily play critical roles in the control of normal and neoplastic proliferation. These proteins relay signals from Tyr-kinases at the plasma membrane to the nucleus via a network of Ser/Thr kinases that includes the MAP kinase (Raf-MEK-ERK) pathway. Kinase suppressor of Ras (KSR-1) was discovered in Drosophila in a genetic screen that identified mutations that suppress constitutively active Ras mutants. Connector enhancer of KSR (CNK) was found in a similar screen to identify mutations that enhance the KSR- dependent phenotype. Drosophila CNK contains a sterile alpha motif (SAM), a conserved region in CNK (CRIC), and a PDZ domain in the N-terminal region, a proline-rich and a plecstrin homology (PH) domain in the central region, and a C-terminal Pro-rich domain. The human homologue of CNK (hCNK1) contains similar N-terminal and central domains, but is 713 amino acids in length compared to 1557 amino acids for Drosophila CNK. In Drosophila, the N-terminal region of CNK facilitates binding to RAS, while the C-terminal region inhibits RAS- and RAF-dependent signaling. Thus, CNK may be important for regulation of both RAS- and RAF-dependent signaling.
Synonyms: Connector enhancer of KSR

Poids moléculaire: 79-100 kDa