Bcl-2 anticorps

N° du produit ABIN968975

3+ publications sont disponibles pour ce produit. L’anticorps anti-Bcl-2 Monoclonal produit chez le Souris a été validé pour IHC, FACS, ELISA et ICC. Il convient pour la détection de Bcl-2 dans des échantillons provenant de Humain et Souris. }

Aperçu rapide pour Bcl-2 anticorps (ABIN968975)

Antigène: Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Bcl-2 est non-conjugé

Application: Immunohistochemistry (IHC), Flow Cytometry (FACS), ELISA, Immunocytochemistry (ICC)

Clone: 8E12

Détail du produit anti-Bcl-2 anticorps

Fonction: BCL-2 Antibody

Purification: Ascitic fluid

Immunogène: Synthetic peptide corresponding to residues surrounding BCL-2, conjugated to KLH.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-Bcl-2 (ABIN968975)

Choi, Feng, Yoon: "FKBP38 protects Bcl-2 from caspase-dependent degradation." dans: The Journal of biological chemistry, Vol. 285, Issue 13, pp. 9770-9, (2010) (PubMed).

Munda, Hajdinjak, Kavalar, Stiblar Martincic: "p53, Bcl-2 and AgNOR tissue markers: model approach in predicting prostate cancer characteristics." dans: The Journal of international medical research, Vol. 37, Issue 6, pp. 1868-76, (2010) (PubMed).

Murphy, Green, Adams, Squire, Kuo, McKay: "Pharmacogenomics in the curricula of colleges and schools of pharmacy in the United States." dans: American journal of pharmaceutical education, Vol. 74, Issue 1, pp. 7, (2010) (PubMed).

Détails sur Bcl-2

Antigène: Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))

Autre désignation: BCL-2

Sujet: This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma.Tissue specificity: Expressed in a variety of tissues.

Poids moléculaire: 26 kDa

ID gène: 596

UniProt: P10415

Pathways: Signalisation MAPK, Signalisation PI3K-Akt, Apoptose, Caspase Cascade in Apoptosis, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagy, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling