Caspase 8 anticorps

N° du produit ABIN969003

Cet anticorps anti-Caspase 8 est un anticorps Souris Monoclonal détectant Caspase 8 dans WB, IHC, ELISA et FACS. Adapté pour Humain, Souris, Rat et Singe. Ce Primary Antibody a été cité dans 2+ publications.

Aperçu rapide pour Caspase 8 anticorps (ABIN969003)

Antigène: Caspase 8 (CASP8)

Reactivité: Humain, Souris, Rat, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Caspase 8 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Clone: 1H11

Détail du produit anti-Caspase 8 anticorps

Fonction: CASP8 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human CASP8 expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-Caspase 8 (ABIN969003)

Fulda: "Caspase-8 in cancer biology and therapy." dans: Cancer letters, Vol. 281, Issue 2, pp. 128-33, (2009) (PubMed).

Jani, Gobejishvili, Hote, Barve, Joshi-Barve, Kharebava, Suttles, Chen, McClain, Barve: "Inhibition of methionine adenosyltransferase II induces FasL expression, Fas-DISC formation and caspase-8-dependent apoptotic death in T leukemic cells." dans: Cell research, Vol. 19, Issue 3, pp. 358-69, (2009) (PubMed).

Détails sur Caspase 8

Antigène: Caspase 8 (CASP8)

Autre désignation: CASP8

Sujet: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.

Poids moléculaire: 26 kDa

ID gène: 841

UniProt: Q14790

Pathways: Apoptose, Caspase Cascade in Apoptosis, Signalisation TLR, Activation of Innate immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades