Integrin beta 2 anticorps

N° du produit ABIN969014

L’anticorps Souris Monoclonal anti-Integrin beta 2 a été validé pour ELISA et ICC. Il convient pour détecter Integrin beta 2 dans des échantillons de Humain et Souris. Il y a 3+ publications disponibles.

Aperçu rapide pour Integrin beta 2 anticorps (ABIN969014)

Antigène: Integrin beta 2 (ITGB2)

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Integrin beta 2 est non-conjugé

Application: ELISA, Immunocytochemistry (ICC)

Clone: 10E12

Détail du produit anti-Integrin beta 2 anticorps

Fonction: CD18 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of CD18 expressed in E. Coli.

Isotype: IgG2b

Information d'application

Indications d'application:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-Integrin beta 2 (ABIN969014)

Chakrabarti, Patel: "The atypical zeta (zeta) isoform of protein kinase C regulates CD11b/CD18 activation in human neutrophils." dans: Microcirculation (New York, N.Y. : 1994), Vol. 15, Issue 6, pp. 555-67, (2008) (PubMed).

Doisne, Castaigne, Deruyffelaere, Dieu-Nosjean, Chamot, Alcaide-Loridan, Charron, Al-Daccak: "The context of HLA-DR/CD18 complex in the plasma membrane governs HLA-DR-derived signals in activated monocytes." dans: Molecular immunology, Vol. 45, Issue 3, pp. 709-18, (2007) (PubMed).

Li, Tang, Puan, Law, Tan: "The cytosolic protein talin induces an intermediate affinity integrin alphaLbeta2." dans: The Journal of biological chemistry, Vol. 282, Issue 33, pp. 24310-9, (2007) (PubMed).

Détails sur Integrin beta 2

Antigène: Integrin beta 2 (ITGB2)

Autre désignation: CD18

Sujet: CD18, also known as ITGB2 (integrin beta chain beta 2). Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. CD18 is expressed by most leucocytes. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene.

Poids moléculaire: 85 kDa

ID gène: 3689

UniProt: P05107

Pathways: Signalisation NF-kappaB, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation