Crk anticorps

N° du produit ABIN969062

L’anticorps Souris Monoclonal anti-Crk a été validé pour ELISA, IHC, ICC et FACS. Il convient pour détecter Crk dans des échantillons de Humain. Il y a 2+ publications disponibles.

Aperçu rapide pour Crk anticorps (ABIN969062)

Antigène: Crk (CRK) (V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian) (CRK))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Crk est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Clone: 3G11C1

Détail du produit anti-Crk anticorps

Fonction: CRK Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human CRK expressed in E. Coli.

Isotype: IgG2b

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-Crk (ABIN969062)

Watanabe, Tsuda, Tanaka, Ohba, Kawaguchi, Majima, Sawa, Minami: "Adaptor protein Crk induces Src-dependent activation of p38 MAPK in regulation of synovial sarcoma cell proliferation." dans: Molecular cancer research : MCR, Vol. 7, Issue 9, pp. 1582-92, (2009) (PubMed).

Tanaka: "[Biological roles of signaling adaptor protein CRK]." dans: Seikagaku. The Journal of Japanese Biochemical Society, Vol. 81, Issue 5, pp. 361-76, (2009) (PubMed).

Détails sur Crk

Antigène: Crk (CRK) (V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian) (CRK))

Autre désignation: CRK

Sujet: This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.

Poids moléculaire: 42 kDa

ID gène: 1398

UniProt: P46108

Pathways: Neurotrophin Signaling Pathway, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor