CSK anticorps

N° du produit ABIN969069

Cet anticorps anti-CSK est un anticorps Souris Monoclonal détectant CSK dans WB, ELISA, ICC et FACS. Adapté pour Humain, Souris, Rat et Singe. Ce Primary Antibody a été cité dans 3+ publications.

Aperçu rapide pour CSK anticorps (ABIN969069)

Antigène: CSK (C-Src tyrosine Kinase (CSK))

Reactivité: Humain, Souris, Rat, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CSK est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)

Clone: 5F3

Détail du produit anti-CSK anticorps

Fonction: CSK Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human CSK expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-CSK (ABIN969069)

Levy, Ehret, Rice, Verwoert, Launer, Dehghan, Glazer, Morrison, Johnson, Aspelund, Aulchenko, Lumley, Köttgen, Vasan, Rivadeneira, Eiriksdottir, Guo, Arking, Mitchell, Mattace-Raso, Smith, Taylor et al.: "Genome-wide association study of blood pressure and hypertension. ..." dans: Nature genetics, Vol. 41, Issue 6, pp. 677-87, (2010) (PubMed).

Ho, Levy, Rose, Johnson, Ridker, Chasman: "Discovery and replication of novel blood pressure genetic loci in the Women's Genome Health Study." dans: Journal of hypertension, Vol. 29, Issue 1, pp. 62-9, (2010) (PubMed).

Kreil, Hochhaus, Cross, Chase: "A high-throughput candidate gene mutation screen in lymphoproliferative and myeloproliferative neoplasias." dans: Leukemia research, Vol. 33, Issue 9, pp. e168-9, (2009) (PubMed).

Détails sur CSK

Antigène: CSK (C-Src tyrosine Kinase (CSK))

Autre désignation: CSK

Sujet: Carboxy-terminal Src kinase (Csk) is a ubiquitously expressed nonreceptor tyrosine kinase that negatively regulates the Src family kinases (SFK) by phosphorylation of the SFK carboxy-terminal tyrosine. Phosphorylated carboxy-terminal tyrosine binds to the SH2 domain of SFK intramolecularly and leads to folding and inactivation of the SFK . This Csk-catalyzed SFK tyrosine phosphorylation is highly specific and exclusive. The SFK carboxy-terminal tyrosine is the only known physiological substrate of Csk .Tissue specificity: Expressed in lung and macrophages.

Poids moléculaire: 50 kDa

ID gène: 1445

UniProt: P41240

Pathways: TCR Signaling, EGFR Signaling Pathway, Cell-Cell Junction Organization, CXCR4-mediated Signaling Events