CTNNB1 anticorps
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- Antigène Voir toutes CTNNB1 Anticorps
- CTNNB1 (Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp CTNNB1 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)
- Purification
- purified
- Immunogène
- Purified recombinant fragment of human CTNNB1 expressed in E. coli.
- Clone
- 4D5
- Isotype
- IgG1
- Top Product
- Discover our top product CTNNB1 Anticorps primaire
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- Indications d'application
- ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Ascitic fluid containing 0.03 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- 4°C, -20°C for long term storage
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Prevalence of mutations in APC, CTNNB1, and BRAF in Tunisian patients with sporadic colorectal cancer." dans: Cancer genetics and cytogenetics, Vol. 187, Issue 1, pp. 12-8, (2008) (PubMed).
: "Relation among p130Cas, E-cadherin and beta-catenin expression, clinicopathologic significance and prognosis in human hepatocellular carcinoma." dans: Hepatobiliary & pancreatic diseases international : HBPD INT, Vol. 7, Issue 5, pp. 490-6, (2008) (PubMed).
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Prevalence of mutations in APC, CTNNB1, and BRAF in Tunisian patients with sporadic colorectal cancer." dans: Cancer genetics and cytogenetics, Vol. 187, Issue 1, pp. 12-8, (2008) (PubMed).
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- Antigène
- CTNNB1 (Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1))
- Autre désignation
- CTNNB1 (CTNNB1 Produits)
- Synonymes
- anticorps Jup, anticorps LOC100217813, anticorps CTNNB1, anticorps CTNNB, anticorps Bfc, anticorps Catnb, anticorps Mesc, anticorps ctnnb, anticorps id:ibd2058, anticorps wu:fb73e10, anticorps wu:fi81c06, anticorps wu:fk25h01, anticorps ctnnb1, anticorps CHBCAT, anticorps MRD19, anticorps armadillo, anticorps beta-catenin, anticorps catenin beta 1, anticorps catenin (cadherin associated protein), beta 1, anticorps catenin (cadherin-associated protein), beta 1, anticorps catenin beta 1 S homeolog, anticorps catenin beta 1 L homeolog, anticorps CTNNB1, anticorps Ctnnb1, anticorps ctnnb1, anticorps ctnnb1.S, anticorps ctnnb1.L
- Sujet
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Description: The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. The distinct peripheral cytosolic proteins, alpha, beta and gamma catenin (102, 94 and 86 kDa) are found in many tissues and bind to the conserved cytoplasmic tail domain of the cell adhesion cadherins. Catenins link E cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt1 proto oncogene. The central core region of beta catenin is involved in mediation of cadherin catenin complex interaction with EGFR. Beta-Catenin-mediated signalling is involved at several stages of vertebrate neural development.
Aliases: CTNNB, FLJ25606, FLJ37923, DKFZp686D02253, CTNNB1
- Poids moléculaire
- 85 kDa
- ID gène
- 1499
- HGNC
- 1499
- Pathways
- Signalisation WNT, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Tube Formation, Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2
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