DLK1 anticorps

N° du produit ABIN969086

L’anticorps Souris Monoclonal anti-DLK1 a été validé pour ELISA, FACS et ICC. Il convient pour détecter DLK1 dans des échantillons de Humain. Il y a 2+ publications disponibles.

Aperçu rapide pour DLK1 anticorps (ABIN969086)

Antigène: DLK1 (delta-Like 1 Homolog (Drosophila) (DLK1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp DLK1 est non-conjugé

Application: ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Clone: 3A10

Détail du produit anti-DLK1 anticorps

Fonction: DLK1 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human DLK1 expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-DLK1 (ABIN969086)

Espina, Méndez-Vidal, Moreno-Mateos, Sáez, Romero-Franco, Japón, Pintor-Toro: "Induction of Dlk1 by PTTG1 inhibits adipocyte differentiation and correlates with malignant transformation." dans: Molecular biology of the cell, Vol. 20, Issue 14, pp. 3353-62, (2009) (PubMed).

Katrincsakova, Takeda, Urbankova, Michaux, Jarosova, Vandenberghe, Georges, Charlier, Wlodarska: "Methylation analysis of the imprinted DLK1-GTL2 domain supports the random parental origin of the IGH-involving del(14q) in B-cell malignancies." dans: Epigenetics, Vol. 4, Issue 7, pp. 469-75, (2009) (PubMed).

Détails sur DLK1

Antigène: DLK1 (delta-Like 1 Homolog (Drosophila) (DLK1))

Autre désignation: DLK1

Sujet: This gene encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes, it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance, this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass.

Poids moléculaire: 41 kDa

ID gène: 8788

UniProt: P80370