MAPK6 anticorps

N° du produit ABIN969115

Cet anticorps Souris Monoclonal détecte spécifiquement MAPK6 dans ELISA et FACS. Il présente une réactivité envers Humain et a été mentionné dans 2+ publications.

Aperçu rapide pour MAPK6 anticorps (ABIN969115)

Antigène: MAPK6 (Mitogen-Activated Protein Kinase 6 (MAPK6))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MAPK6 est non-conjugé

Application: ELISA, Flow Cytometry (FACS)

Clone: 4E8

Détail du produit anti-MAPK6 anticorps

Fonction: ERK3 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human ERK3 expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-MAPK6 (ABIN969115)

Klinger, Turgeon, Lévesque, Wood, Aagaard-Tillery, Meloche: "Loss of Erk3 function in mice leads to intrauterine growth restriction, pulmonary immaturity, and neonatal lethality." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 39, pp. 16710-5, (2009) (PubMed).

Déléris, Rousseau, Coulombe, Rodier, Tanguay, Meloche: "Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5." dans: Journal of cellular physiology, Vol. 217, Issue 3, pp. 778-88, (2008) (PubMed).

Détails sur MAPK6

Antigène: MAPK6 (Mitogen-Activated Protein Kinase 6 (MAPK6))

Autre désignation: ERK3

Sujet: The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. (provided by RefSeq) Tissue specificity: Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts

Poids moléculaire: 105 kDa

ID gène: 5597

UniProt: Q16659

Pathways: Signalisation MAPK, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation, Hepatitis C