MAP2K7 anticorps

N° du produit ABIN969271

Cet anticorps Souris Monoclonal détecte spécifiquement MAP2K7 dans ELISA, IHC, ICC et FACS. Il présente une réactivité envers Humain et a été mentionné dans 2+ publications.

Aperçu rapide pour MAP2K7 anticorps (ABIN969271)

Antigène: MAP2K7 (Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MAP2K7 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Clone: 4E5

Détail du produit anti-MAP2K7 anticorps

Fonction: MAP2K7 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human MAP2K7 expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-MAP2K7 (ABIN969271)

Nakagawa, Sugahara, Yamasaki, Kajiho, Takahashi, Hirayama, Minami, Ohta, Watanabe, Hata, Katada, Nishina: "Filamin associates with stress signalling kinases MKK7 and MKK4 and regulates JNK activation." dans: The Biochemical journal, Vol. 427, Issue 2, pp. 237-45, (2010) (PubMed).

Yoshizawa, Hammaker, Sweeney, Boyle, Firestein: "Synoviocyte innate immune responses: I. Differential regulation of interferon responses and the JNK pathway by MAPK kinases." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 5, pp. 3252-8, (2008) (PubMed).

Détails sur MAP2K7

Antigène: MAP2K7 (Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7))

Autre désignation: MAP2K7

Sujet: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined.

Poids moléculaire: 48 kDa

UniProt: O14733

Pathways: Signalisation MAPK, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, BCR Signaling