NFKBIB anticorps

N° du produit ABIN969314

L’anticorps Souris Monoclonal anti-NFKBIB a été validé pour WB et ELISA. Il convient pour détecter NFKBIB dans des échantillons de Humain. Il y a 3+ publications disponibles.

Aperçu rapide pour NFKBIB anticorps (ABIN969314)

Antigène: NFKBIB (NF-kappa-B inhibitor beta (NFKBIB))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NFKBIB est non-conjugé

Application: Western Blotting (WB), ELISA

Clone: 7B4

Détail du produit anti-NFKBIB anticorps

Fonction: NFKBIB Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human NFKBIB expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-NFKBIB (ABIN969314)

Yerges, Klei, Cauley, Roeder, Kammerer, Moffett, Ensrud, Nestlerode, Marshall, Hoffman, Lewis, Lang, Barrett-Connor, Ferrell, Orwoll, Zmuda: "High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men." dans: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 24, Issue 12, pp. 2039-49, (2009) (PubMed).

Chen, Vallee, Wu, Vu, Sondek, Ghosh: "Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras." dans: Molecular and cellular biology, Vol. 24, Issue 7, pp. 3048-56, (2004) (PubMed).

Abid, Schoots, Spokes, Wu, Mawhinney, Aird: "Vascular endothelial growth factor-mediated induction of manganese superoxide dismutase occurs through redox-dependent regulation of forkhead and IkappaB/NF-kappaB." dans: The Journal of biological chemistry, Vol. 279, Issue 42, pp. 44030-8, (2004) (PubMed).

Détails sur NFKBIB

Antigène: NFKBIB (NF-kappa-B inhibitor beta (NFKBIB))

Autre désignation: NFKBIB

Sujet: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further IKBA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.Tissue specificity: Expressed in all tissues examined.

Poids moléculaire: 45 kDa

ID gène: 4793

UniProt: Q15653

Pathways: Signalisation NF-kappaB, Activation of Innate immune Response, Maintenance of Protein Location, Toll-Like Receptors Cascades