PDPK1 anticorps

N° du produit ABIN969347

Il existe 3+ publications pour ce produit. L’anticorps anti-PDPK1 Monoclonal Souris est utilisé pour la détection de PDPK1 dans des échantillons de Humain, Rat et Singe. Il a été validé pour WB, ELISA, IHC, ICC et FACS.

Aperçu rapide pour PDPK1 anticorps (ABIN969347)

Antigène: PDPK1 (3-phosphoinositide Dependent Protein Kinase-1 (PDPK1))

Reactivité: Humain, Rat, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PDPK1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Clone: 4A11

Détail du produit anti-PDPK1 anticorps

Fonction: PDK1 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human PDK1 expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-PDPK1 (ABIN969347)

Weisberg, Banerji, Wright, Barrett, Ray, Moreno, Catley, Jiang, Hall-Meyers, Sauveur-Michel, Stone, Galinsky, Fox, Kung, Griffin: "Potentiation of antileukemic therapies by the dual PI3K/PDK-1 inhibitor, BAG956: effects on BCR-ABL- and mutant FLT3-expressing cells." dans: Blood, Vol. 111, Issue 7, pp. 3723-34, (2008) (PubMed).

Pinner, Sahai: "PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE." dans: Nature cell biology, Vol. 10, Issue 2, pp. 127-37, (2008) (PubMed).

Seong, Jung, Kim, Ha: "3-Phosphoinositide-dependent PDK1 negatively regulates transforming growth factor-beta-induced signaling in a kinase-dependent manner through physical interaction with Smad proteins." dans: The Journal of biological chemistry, Vol. 282, Issue 16, pp. 12272-89, (2007) (PubMed).

Détails sur PDPK1

Antigène: PDPK1 (3-phosphoinositide Dependent Protein Kinase-1 (PDPK1))

Autre désignation: PDK1

Sujet: Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. (provided by RefSeq). Tissue specificity: Expressed predominantly in the heart.

Poids moléculaire: 44 kDa

ID gène: 5163

UniProt: Q15118

Pathways: Signalisation PI3K-Akt, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Regulation of Cell Size, Skeletal Muscle Fiber Development, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals