PSMB8 anticorps

N° du produit ABIN969371

Détail du produit anti-PSMB8 anticorps

Antigène: PSMB8 (Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) (PSMB8))

Reactivité: Humain, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PSMB8 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC)

Purification: purified

Immunogène: Purified recombinant fragment of human PSMB8 expressed in E. coli.

Clone: 1A5

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: 4°C, -20°C for long term storage

Références pour anticorps anti-PSMB8 (ABIN969371)

Camarena, Aquino-Galvez, Falfán-Valencia, Sánchez, Montaño, Ramos, Juárez, García-de-Alba, Granados, Selman: "PSMB8 (LMP7) but not PSMB9 (LMP2) gene polymorphisms are associated to pigeon breeder's hypersensitivity pneumonitis." dans: Respiratory medicine, Vol. 104, Issue 6, pp. 889-94, (2010) (PubMed).

Mehta, Jordanova, Corver, van Wezel, Uh, Kenter, Jan Fleuren: "Single nucleotide polymorphisms in antigen processing machinery component ERAP1 significantly associate with clinical outcome in cervical carcinoma." dans: Genes, chromosomes & cancer, Vol. 48, Issue 5, pp. 410-8, (2009) (PubMed).

Détails sur PSMB8

Antigène: PSMB8 (Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) (PSMB8))

Autre désignation: PSMB8 (PSMB8 Produits)

Synonymes: anticorps ALDD, anticorps D6S216, anticorps D6S216E, anticorps JMP, anticorps LMP7, anticorps NKJO, anticorps PSMB5i, anticorps RING10, anticorps ATP6V0D2, anticorps lmp7, anticorps prosome, anticorps macropain, anticorps Lmp-7, anticorps Lmp7, anticorps Ring10, anticorps proteasome subunit beta 8, anticorps proteasome subunit beta 8A, anticorps proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7), anticorps PSMB8, anticorps psmb8a, anticorps Psmb8

Sujet:

Description: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified, both isoforms are processed to yield the same mature subunit.

Aliases: JMP, LMP7, D6S216, PSMB5i, RING10, D6S216E, MGC1491

Poids moléculaire: 30 kDa

ID gène: 5696

HGNC: 5696

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA