LKB1 anticorps

N° du produit ABIN969424

Cet anticorps Souris Monoclonal détecte spécifiquement LKB1 dans WB, ELISA et FACS. Il présente une réactivité envers Humain, Souris et Singe et a été mentionné dans 3+ publications.

Aperçu rapide pour LKB1 anticorps (ABIN969424)

Antigène: LKB1 (STK11) (serine/threonine Kinase 11 (STK11))

Reactivité: Humain, Souris, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp LKB1 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Clone: 4H12

Détail du produit anti-LKB1 anticorps

Fonction: STK11 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human STK11 expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-LKB1 (ABIN969424)

Al-Nashash, Fatoo, Mirza, Ahmed, Agrawal, Thakor, All: "Spinal cord injury detection and monitoring using spectral coherence." dans: IEEE transactions on bio-medical engineering, Vol. 56, Issue 8, pp. 1971-9, (2009) (PubMed).

Shaw: "Tumor suppression by LKB1: SIK-ness prevents metastasis." dans: Science signaling, Vol. 2, Issue 86, pp. pe55, (2009) (PubMed).

Cheng, Liu, Wang, Zou, Santiago, Garbitt, Gjoerup, Iglehart, Miron, Richardson, Hahn, Zhao: "SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis." dans: Science signaling, Vol. 2, Issue 80, pp. ra35, (2009) (PubMed).

Détails sur LKB1

Antigène: LKB1 (STK11) (serine/threonine Kinase 11 (STK11))

Autre désignation: STK11

Sujet: Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases. Tumor suppressor.serine/threonine kinase 11,with two alternatively spliced isoforms,expressed in all tissues,strongly homolog of Xenopus early embryonic kinase 1 (XEEK1),tumor suppressor gene in hamartomas syndrome and in left sided colon carcinogenesis,mutated in sporadic testicular cancer,malignant melanomas and laryngeal tumors,playing a minor role in the development of ovarian carcinoma.LKB1 is a potential target for atherosclerosis and cancer and is shown to be mutated in patients with Peutz-Jeghers cancer syndrome. Tissue specificity: Ubiquitously expressed. Strongest expression in testis and fetal liver.

Poids moléculaire: 54 kDa

ID gène: 6794

UniProt: Q15831

Pathways: AMPK Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, L'effet Warburg