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MCL-1 anticorps

MCL1 Reactivité: Humain WB, ELISA, IHC, ICC Hôte: Souris Monoclonal 8C6 unconjugated
N° du produit ABIN969485
  • Antigène Voir toutes MCL-1 (MCL1) Anticorps
    MCL-1 (MCL1) (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1))
    Reactivité
    • 148
    • 83
    • 71
    • 6
    • 5
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 145
    • 8
    • 2
    • 1
    Souris
    Clonalité
    • 139
    • 19
    Monoclonal
    Conjugué
    • 73
    • 12
    • 12
    • 10
    • 7
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MCL-1 est non-conjugé
    Application
    • 124
    • 65
    • 52
    • 45
    • 27
    • 26
    • 22
    • 22
    • 10
    • 10
    • 7
    • 5
    • 4
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)
    Purification
    purified
    Immunogène
    Purified recombinant fragment of human MCL-1 expressed in E. coli.
    Clone
    8C6
    Isotype
    IgG1
    Top Product
    Discover our top product MCL1 Anticorps primaire
  • Indications d'application
    ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified antibody in PBS containing 0.03 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    4°C, -20°C for long term storage
  • Richert, Schwertfeger, Ryder, Anderson: "An atlas of mouse mammary gland development." dans: Journal of mammary gland biology and neoplasia, Vol. 5, Issue 2, pp. 227-41, (2001) (PubMed).

    MacLachlan, Hébert: "Statement concerning euthanasia and physician-assisted suicide. Ethics Committee of the College of Family Physicians of Canada." dans: Canadian family physician Médecin de famille canadien, Vol. 46, pp. 254-6, 264-7, (2000) (PubMed).

  • Antigène
    MCL-1 (MCL1) (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1))
    Autre désignation
    MCL-1 (MCL1 Produits)
    Synonymes
    anticorps BCL2L3, anticorps EAT, anticorps MCL1-ES, anticorps MCL1L, anticorps MCL1S, anticorps Mcl-1, anticorps TM, anticorps bcl2-L-3, anticorps mcl1/EAT, anticorps AW556805, anticorps mcl-1, anticorps fb72f02, anticorps wu:fb70a08, anticorps wu:fb72f02, anticorps zfMLP1, anticorps zfMcl-1a, anticorps zgc:109835, anticorps zgc:109763, anticorps E3, anticorps E3-2, anticorps RNE3, anticorps RNU107, anticorps SNORA63A, anticorps elF-4AII, anticorps MCL1, BCL2 family apoptosis regulator, anticorps myeloid cell leukemia sequence 1, anticorps MCL1, BCL2 family apoptosis regulator a, anticorps MCL1, BCL2 family apoptosis regulator b, anticorps small nucleolar RNA, H/ACA box 63, anticorps MCL1, anticorps Mcl1, anticorps mcl1a, anticorps mcl1b, anticorps SNORA63
    Sujet

    Description: Mcl-1 (Myeloid cell leukemia-1) is Bcl-2-related and was identified as an early-induction gene that increased in expression during the differentiation of human myeloblastic leukemia cell ML-1, or exposure to different DNA damaging agents. The level of Mcl-1 is decreased in peripheral B lymphocytes undergoing apoptosis following treatment with apoptotic stimuli such as TGF-alpha 1 and forskolin. Expression of Mcl-1 is able to delay apoptosis induced by over-expression of c-myc in CHO 5AHSmyc cells. In hematopoietic FDC-P1 cells, Mcl-1 interacts with another Bcl-2-related protein, Bax, and prolongs cell viability after treatment with different apoptotic reagents.This monoclonal antibody detected a 37kd MCL1 in BCBL-1 cell lysate.

    Aliases: EAT, MCL1L, MCL1S

    Poids moléculaire
    37 kDa
    ID gène
    4170
    HGNC
    4170
    Pathways
    Signalisation MAPK
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