VAV1 anticorps (AA 121-324)

N° du produit ABIN969581

L’anticorps Souris Monoclonal anti-VAV1 a été validé pour WB, ELISA et FACS. Il convient pour détecter VAV1 dans des échantillons de Humain. Il y a 2+ publications disponibles.

Aperçu rapide pour VAV1 anticorps (AA 121-324) (ABIN969581)

Antigène: VAV1 (Vav 1 Oncogene (VAV1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp VAV1 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Clone: 2E11

Détail du produit anti-VAV1 anticorps

Épitope: AA 121-324

Fonction: VAV1 Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human VAV1 (AA: 121-324) expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-VAV1 (ABIN969581)

Bertagnolo, Nika, Brugnoli, Bonora, Grassilli, Pinton, Capitani: "Vav1 is a crucial molecule in monocytic/macrophagic differentiation of myeloid leukemia-derived cells." dans: Cell and tissue research, Vol. 345, Issue 1, pp. 163-75, (2011) (PubMed).

Yin, Wan, Li, Du, Zhang, Zhou, Cao: "The distinct role of guanine nucleotide exchange factor Vav1 in Bcl-2 transcription and apoptosis inhibition in Jurkat leukemia T cells." dans: Acta pharmacologica Sinica, Vol. 32, Issue 1, pp. 99-107, (2011) (PubMed).

Détails sur VAV1

Antigène: VAV1 (Vav 1 Oncogene (VAV1))

Autre désignation: VAV1

Sujet: The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.

Poids moléculaire: 98.3 kDa

UniProt: P15498

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, CXCR4-mediated Signaling Events, BCR Signaling