BCCIP Produits
(BRCA2 and CDKN1A Interacting Protein (BCCIP))
Catégories
This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
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Catégories BCCIP en vedette
BCCIP Anticorps
High quality antibodies with extensive validation data.
BCCIP Kits ELISA
Reliable ELISA kits for a wide range of species.
BCCIP Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
BCCIP recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IF, IHC (p), ICC
Validations
- (4)
N° du produit
ABIN2856892
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC
Validations
- (4)
N° du produit
ABIN6137485
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IF
Validations
- (3)
N° du produit
ABIN527937
Quantité
50 μg
Fiche technique
Fiche technique
BCCIP recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6730078
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Validations
N° du produit
ABIN1124123
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Cow
Analytical Method
Validations
N° du produit
ABIN1124121
Quantité
96 tests
Fiche technique
Fiche technique
BCCIP recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7122031
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1346518
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1346520
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits BCCIP
: "The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repair." dans: Molecular and cellular biology, Vol. 25, Issue 5, pp. 1949-57, (2005) (PubMed).: "Inhibition of G1 to S cell cycle progression by BCCIP beta." dans: Cell cycle (Georgetown, Tex.), Vol. 3, Issue 3, pp. 343-8, (2004) (PubMed).
: "Unique de novo mutation of BRCA2 in a woman with early onset breast cancer." dans: Journal of medical genetics, Vol. 39, Issue 2, pp. 126-8, (2002) (PubMed).
: "Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2." dans: Oncogene, Vol. 20, Issue 3, pp. 336-45, (2001) (PubMed).
: "TOK-1, a novel p21Cip1-binding protein that cooperatively enhances p21-dependent inhibitory activity toward CDK2 kinase." dans: The Journal of biological chemistry, Vol. 275, Issue 40, pp. 31145-54, (2000) (PubMed).
Synonymes et noms alternatifs relatifs à BCCIP
BRCA2 and CDKN1A interacting protein (BCCIP), BRCA2 and CDKN1A interacting protein (bccip), BRCA2 and CDKN1A interacting protein L homeolog (bccip.L), BRCA2 and CDKN1A interacting protein (Bccip), 1110013J05Rik, BCCIP, DKFZp459K2416, MGC82792, MGC89311, mp:zf637-1-000774, tok-1, TOK-1, TOK1, zgc:110272Protein level used designations for BCCIP
- BRCA2 and CDKN1A interacting protein
- protein BCCIP homolog
- BRCA2 and CDKN1A-interacting protein
- bccip-like
- BCCIPalpha
- BCCIPbeta
- BRCA2 and Cip1/p21 interacting protein
- TOK-1alpha
- TOK-1beta
- cdk inhibitor p21 binding protein
- p21- and CDK-associated protein 1
- protein TOK-1
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