This gene is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the upper airways and nasopharyngeal regions. The exact biological function of this gene is not known, however, it has been suggested to be involved in inflammatory responses to irritants in the upper airways. It may also serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. Multiple transcript variants resulting from alternative splicing in the 3' UTR have been detected, but the full-length nature of only three are known. [provided by RefSeq, Aug 2011].
Budding, van de Graaf, Hoefnagel, Hack, Otten: "Anti-BPIFA1/SPLUNC1: a new autoantibody prevalent in patients with endstage cystic fibrosis." dans: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, Vol. 13, Issue 3, pp. 281-8, (2014) (PubMed).
Nicholas, Skipp, Barton, Singh, Bagmane, Mould, Angco, Ward, Guha-Niyogi, Wilson, Howarth, Davies, Rennard, OConnor, Djukanovic: "Identification of lipocalin and apolipoprotein A1 as biomarkers of chronic obstructive pulmonary disease." dans: American journal of respiratory and critical care medicine, Vol. 181, Issue 10, pp. 1049-60, (2010) (PubMed).
Pseudonymes pour BPIFA1 Protéines
BPI fold containing family A member 1 (BPIFA1) Protéines BPI fold containing family A, member 1 (Bpifa1) Protéines bA49G10.5 Protéines LUNX Protéines NASG Protéines PLUNC Protéines Plunc Protéines SPLUNC1 Protéines SPURT Protéines