BRCA1 Produits
(Breast Cancer 1 (BRCA1))
Catégories
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009].
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Catégories BRCA1 en vedette
BRCA1 Anticorps
High quality antibodies with extensive validation data.
BRCA1 Kits ELISA
Reliable ELISA kits for a wide range of species.
BRCA1 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
BRCA1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (6)
N° du produit
ABIN7433579
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, IHC, IF
Validations
- (7)
N° du produit
ABIN7265138
Quantité
200 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC, ELISA
Validations
- (1)
- (5)
N° du produit
ABIN1724848
Quantité
0.1 mg
Fiche technique
Fiche technique
BRCA1 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6965234
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6954188
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Qualitative Cell ELISA
Validations
N° du produit
ABIN1380829
Quantité
2 x 96 tests
Fiche technique
Fiche technique
BRCA1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1346845
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1346847
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7504943
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits BRCA1
: "Single-dose radiotherapy disables tumor cell homologous recombination via ischemia/reperfusion injury. ..." dans: The Journal of clinical investigation, Vol. 129, Issue 2, pp. 786-801, (2019) (PubMed).: "PARP inhibitor veliparib and HDAC inhibitor SAHA synergistically co-target the UHRF1/BRCA1 DNA damage repair complex in prostate cancer cells." dans: Journal of experimental & clinical cancer research : CR, Vol. 37, Issue 1, pp. 153, (2018) (PubMed).
: "Therapeutic Impact of Nanoparticle Therapy Targeting Tumor-Associated Macrophages." dans: Molecular cancer therapeutics, Vol. 17, Issue 1, pp. 96-106, (2018) (PubMed).
: "Dianhydrogalactitol induces replication-dependent DNA damage in tumor cells preferentially resolved by homologous recombination." dans: Cell death & disease, Vol. 9, Issue 10, pp. 1016, (2018) (PubMed).
: "Di (2-ethylhexyl) phthalate exposure impairs meiotic progression and DNA damage repair in fetal mouse oocytes in vitro." dans: Cell death & disease, Vol. 8, Issue 8, pp. e2966, (2017) (PubMed).
: "Artemisinin mimics calorie restriction to trigger mitochondrial biogenesis and compromise telomere shortening in mice." dans: PeerJ, Vol. 3, pp. e822, (2015) (PubMed).
: "Characterization of the platelet-derived growth factor receptor-α-positive cell lineage during murine late lung development." dans: American journal of physiology. Lung cellular and molecular physiology, Vol. 309, Issue 9, pp. L942-58, (2015) (PubMed).
: "Homozygous mutation of MTPAP causes cellular radiosensitivity and persistent DNA double-strand breaks." dans: Cell death & disease, Vol. 5, pp. e1130, (2014) (PubMed).
: "Quantitative measurement of alterations in DNA damage repair (DDR) pathways using single cell network profiling (SCNP)." dans: Journal of translational medicine, Vol. 12, pp. 184, (2014) (PubMed).
: "Validation of the BRCA1 antibody MS110 and the utility of BRCA1 as a patient selection biomarker in immunohistochemical analysis of breast and ovarian tumours." dans: Virchows Archiv : an international journal of pathology, Vol. 462, Issue 3, pp. 269-79, (2013) (PubMed).
Synonymes et noms alternatifs relatifs à BRCA1
BRCA1, DNA repair associated (BRCA1), breast cancer 1 (brca1), breast cancer 1, early onset (LOC755086), breast cancer 1, early onset (Brca1), BRCA1, DNA repair associated (Brca1), breast cancer 1, early onset (BRCA1), breast cancer 1 L homeolog (brca1.L), brca1, BRCA1, BRCAI, brcai, BRCC1, brcc1, BROVCA1, IRIS, iris, LOC100224649, PNCA4, PPP1R53, PSCP, pscp, RNF53, rnf53Protein level used designations for BRCA1
- BRCA1/BRCA2-containing complex, subunit 1
- RING finger protein 53
- breast and ovarian cancer susceptibility protein 1
- breast and ovarian cancer sususceptibility protein 1
- breast cancer type 1 susceptibility protein
- protein phosphatase 1, regulatory subunit 53
- BRCA1 homologue
- breast cancer type 1 susceptibility protein homolog
- breast cancer 1, early onset
- BRCA1 homolog
- breast and ovarian cancer susceptibility protein
- breast cancer associated 1
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