BPTF Produits
(Bromodomain PHD Finger Transcription Factor (BPTF))
Catégories
This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely. [provided by RefSeq, Jul 2008].
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Catégories BPTF en vedette
BPTF Anticorps
High quality antibodies with extensive validation data.
BPTF recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Mouse, Rat
Application
WB, IF (cc), IF (p), ELISA, IHC (p), IHC (fro), ICC
Validations
- (3)
N° du produit
ABIN1386560
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA
Validations
- (2)
- (2)
N° du produit
ABIN968990
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
IHC (p), IF
Validations
- (2)
N° du produit
ABIN5649422
Quantité
100 μL
Fiche technique
Fiche technique
BPTF recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7122052
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (2)
N° du produit
ABIN2669695
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits BPTF
: "Evolution of Yin and Yang isoforms of a chromatin remodeling subunit precedes the creation of two genes." dans: eLife, Vol. 8, (2019) (PubMed).: "Chromatin remodeling by imitation switch (ISWI) class ATP-dependent remodelers is stimulated by histone variant H2A.Z." dans: The Journal of biological chemistry, Vol. 285, Issue 7, pp. 4645-51, (2010) (PubMed).
: "BLNK binds active H-Ras to promote B cell receptor-mediated capping and ERK activation." dans: The Journal of biological chemistry, Vol. 284, Issue 15, pp. 9804-13, (2009) (PubMed).
: "B-cell linker protein prevents aneuploidy by inhibiting cytokinesis." dans: Cancer science, Vol. 99, Issue 12, pp. 2444-54, (2008) (PubMed).
: "Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells." dans: PLoS genetics, Vol. 4, Issue 10, pp. e1000241, (2008) (PubMed).
: "Toward a confocal subcellular atlas of the human proteome." dans: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, (2008) (PubMed).
Synonymes et noms alternatifs relatifs à BPTF
bromodomain PHD finger transcription factor (BPTF), bromodomain PHD finger transcription factor (Bptf), nucleosome-remodeling factor subunit NURF301 (LOC5576547), fetal alzheimer antigen, falz (CpipJ_CPIJ011285), bromodomain PHD finger transcription factor (bptf), 9430093H17Rik, BPTF, FAC1, FALZ, Falz, NURF301Protein level used designations for BPTF
- bromodomain and PHD domain transcription factor
- bromodomain and PHD finger-containing transcription factor
- fetal Alz-50 clone 1 protein
- fetal Alz-50 reactive clone 1
- fetal Alzheimer antigen
- nucleosome remodeling factor, large subunit
- nucleosome-remodeling factor subunit BPTF
- fetal alzheimer antigen, falz
- bromodomain PHD finger transcription factor
- nucleosome-remodeling factor subunit BPTF-like
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