CDK5R1 Produits
(Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1))
Catégories
The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5)\; the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008].
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Catégories CDK5R1 en vedette
CDK5R1 Anticorps
High quality antibodies with extensive validation data.
CDK5R1 Kits ELISA
Reliable ELISA kits for a wide range of species.
CDK5R1 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
CDK5R1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, IF, IP, ICC, AA
Validations
- (1)
- (4)
N° du produit
ABIN361805
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, IF, IP, ICC, AA
Validations
- (4)
N° du produit
ABIN2486463
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, IF, IP, ICC, AA
Validations
- (4)
N° du produit
ABIN2486462
Quantité
100 μg
Fiche technique
Fiche technique
CDK5R1 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6966171
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6966170
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
N° du produit
ABIN5648251
Quantité
96 tests
Fiche technique
Fiche technique
CDK5R1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7122534
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1348963
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN1686721
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits CDK5R1
: "Ganetespib (STA-9090), a nongeldanamycin HSP90 inhibitor, has potent antitumor activity in in vitro and in vivo models of non-small cell lung cancer." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 18, Issue 18, pp. 4973-85, (2012) (PubMed).: "Phosphoregulation of the RNA-binding protein Hu antigen R (HuR) by Cdk5 affects centrosome function." dans: The Journal of biological chemistry, Vol. 287, Issue 38, pp. 32277-87, (2012) (PubMed).
: "CDK5 activator p35 downregulates E-cadherin precursor independently of CDK5." dans: FEBS letters, Vol. 582, Issue 8, pp. 1197-202, (2008) (PubMed).
: "Expression of cyclin-dependent kinase 5 mRNA and protein in the human brain following acute ischemic stroke." dans: Brain pathology (Zurich, Switzerland), Vol. 17, Issue 1, pp. 11-23, (2007) (PubMed).
: "Increased immunoreactivity of cdk5 activators in hippocampal sclerosis." dans: Neuroreport, Vol. 18, Issue 5, pp. 511-6, (2007) (PubMed).
: "Stable association of hsp90 and p23, but Not hsp70, with active human telomerase." dans: The Journal of biological chemistry, Vol. 276, Issue 19, pp. 15571-4, (2001) (PubMed).
: "The p23 molecular chaperones act at a late step in intracellular receptor action to differentially affect ligand efficacies." dans: Genes & development, Vol. 14, Issue 4, pp. 422-34, (2000) (PubMed).
: "Molecular chaperone machines: chaperone activities of the cyclophilin Cyp-40 and the steroid aporeceptor-associated protein p23." dans: Science (New York, N.Y.), Vol. 274, Issue 5293, pp. 1718-20, (1997) (PubMed).
: "Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes." dans: Molecular and cellular biology, Vol. 14, Issue 3, pp. 1956-63, (1994) (PubMed).
Synonymes et noms alternatifs relatifs à CDK5R1
cyclin dependent kinase 5 regulatory subunit 1 (CDK5R1), cyclin-dependent kinase 5, regulatory subunit 1b (p35) (cdk5r1b), cyclin-dependent kinase 5 regulatory subunit 1 (Cdk5r1), S100 calcium binding protein A9 (S100A9), cyclin-dependent kinase 5, regulatory subunit 1 (p35) (Cdk5r1), cyclin-dependent kinase 5, regulatory subunit 1 (p35) L homeolog (cdk5r1.L), cyclin dependent kinase 5 regulatory subunit 1 (Cdk5r1), CDK5P35, CDK5R, Cdk5r, cdk5r1, CDK5R1, D11Bwg0379e, NCK5A, p23, p25, P25/P35, p35, p35nck5a, Xp35.1, zgc:92814Protein level used designations for CDK5R1
- CDK5 activator 1
- TPKII regulatory subunit
- cyclin-dependent kinase 5 activator 1
- cyclin-dependent kinase 5 regulatory subunit 1
- neuronal CDK5 activator
- regulatory partner for CDK5 kinase
- tau protein kinase II 23kDa subunit
- cyclin-dependent kinase 5 regulatory subunit
- cyclin-dependent kinase 5, regulatory subunit 1 (p35)
- p23
- tau protein kinase II 23 kDa subunit
- BEE22
- S100 calcium-binding protein A9
- calgranulin-B
- neutrophil cytosolic 23 kDa protein
- protein S100-A9
- cyclin-dependent kinase 5, regulatory subunit (p35) 1
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