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data suggest that there are significant interactive effects between ABCA1 I883M and ALT levels on HDL (Montrer HSD11B1 Protéines)-C and LDL-C levels.
vaspin (Montrer SERPINA12 Protéines) decreased miR (Montrer MLXIP Protéines)-33a levels, which in turn increased ABCA1 expression and cholesteorl efflux.
ABCA1 rs2230806 had a significant association with prevalence of Type 2 Diabetes.
Confirmed by mRNA and protein expression, the amino acid transporters SLC7A7 (Montrer Slc7a7 Protéines) and SLC38A5 showed marked differences between controls and intrauterine growth restriction/pre-eclampsia and were regulated by both diseases. In contrast, ABCA1 may play an exclusive role in the development of pre-eclempsia.
Single Nucleotide Polymorphism in ABCA1 gene is associated with dyslipidemia.
Increased expression of hepatic ABCA1 transporter is associated with hypercholesterolemia in a cholestatic rat model and primary biliary cholangitis patients.
Review/Meta-analysis: significant association of ABCA1 rs2230806 GG with increased risk of ischemic stroke.
Results showed that ABCA1 participates in the alpha-synuclein transport of cholesterol through the plasma membrane of neuronal cells.
HECTD1 (Montrer HECTD1 Protéines) may be involved in the regulation of ABCA1-mediated cholesterol export from unloaded macrophages to apoA-I (Montrer APOA1 Protéines).
ABCA1 R219K RR+RK genotype frequency in Alzheimer and Parkinson Disease patients was lower than that in normal controls (NC), while ABCA1 R219K KK genotype frequency was significantly higher. ABCA1 R219K R allele was the risk factor inducing abnormal serum levels of ApoA2 (Montrer APOA2 Protéines), LDL, and TG in AD patients, and abnormal levels of serum ABCA1, HDL (Montrer HSD11B1 Protéines), IL-1beta (Montrer IL1B Protéines), IL-6 (Montrer IL6 Protéines), and TNF-alpha (Montrer TNF Protéines) in PD patients.
our results highlight the importance of the LXR (Montrer NR1H3 Protéines)/ABCA1 system in brain pericytes and suggest a new role for these cells in brain cholesterol homeostasis.
The expression and distribution of the bovine ABCA1 transporter using quantitative PCR and the sequencing of the entire ABCA1 coding region, including the proximal promoter region, are reported.
Aortic endothelial cells transcytose high-density lipoproteins by mechanisms that involve either SR-BI (Montrer SCARB1 Protéines) or ABCG1 (Montrer ABCG1 Protéines) but not ABCA1.
ABCA1 promoter variants affect transcription activity and plasma HDL (Montrer HSD11B1 Protéines) level in pigs
ABCA1 was up-regulated in monocytes of hypercholesterolemic pigs via oxidized-LDL and prior to development coronary atherosclerosis.
Both region-specific and ubiquitous (ABCA1) phenotype changes were identified as early prelesional responses of the endothelium to hypercholesterolemia
CSL112 elevation of ABCA1-dependent efflux may target atherosclerotic plaque for cholesterol removal.
It was concluded that quercetin inhibits oxLDLinduced lipid droplets in RAW264.7 cells by upregulation of ABCAl, ABCG1, LXRalpha and downregulation of PCSK9, p53, p21 and p16.
these results suggest that apigenin may attenuate atherogenesis through up-regulating ABCA1-mediated cholesterol efflux and inhibiting inflammation.
TMP upregulated the protein stability of ABCA1 without affecting ABCG1 (Montrer ABCG1 Protéines). Accordingly, TMP regulated the expression of SR-A (Montrer MSR1 Protéines), CD36 (Montrer CD36 Protéines), ABCA1 and ABCG1 (Montrer ABCG1 Protéines) in aortas of ApoE (Montrer APOE Protéines)-/- mice, which resembled the findings observed in macrophages.
HDL3, by interacting with ABCA1, modulates the miR143/145-myocardin axis and prevents the cholesterol-induced gene expression modification in smooth muscle cells regardless of its cholesterol unloading capacity.
(1) ABCA1 maintains optimal hepatocyte PM FC, through intracellular FC trafficking, for efficient insulin (Montrer INS Protéines) signaling; and (2) hepatocyte ABCA1 deletion produces a form of selective insulin (Montrer INS Protéines) resistance so that lipogenesis is suppressed but glucose metabolism remains normal
demonstrates behavior deficits caused by Abca1 deletion in APP (Montrer APP Protéines)/PS1DeltaE9 mouse model at an early stage of amyloid pathology. The basal deficits of Abca1ko, manifested by diminished cognitive performance, prevent them from coping with additional stressors, which is in part due to the impairment of neurite morphology in the hippocampus.
Rutaecarpine was identified to be a candidate that protected ApoE (Montrer APOE Protéines)(-/-) mice from developing atherosclerosis through preferentially promoting activities of ABCA1 and SR-BI (Montrer SCARB1 Protéines) within RCT (Montrer FOXE3 Protéines).
Abca1 has a protective role in atherosclerosis, it exerts detrimental effects on cardiac function after myocardial infarction
Caveolin-1 (Montrer CAV1 Protéines) enhances internalization and degradation of ABCA1 by its association with ABCA1
ABCA1-derived nascent high-density lipoprotein-apolipoprotein AI (Montrer APOA1 Protéines) and lipids metabolically segregate.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency.
ATP-binding cassette sub-family A member 1
, ATP-binding cassette transporter A1
, cholesterol efflux regulatory protein
, ATP-binding cassette, sub-family A (ABC1), member 1
, ATP-binding cassette, sub-family A member 1
, ATP-binding cassette transporter 1
, Cholesterol efflux regulatory protein
, ATP-binding cassette transporter
, ATP-binding cassette, sub-family A member 1-like
, ATP-binding cassette sub-family A member 1-like
, ATP-binding cassette 1
, ATP-binding cassette, sub-family A (ABC1), member 1B