Aperçu des produits pour Chemokine (C-C Motif) Ligand 2 Protéines (CCL2)

Human Chemokine (C-C Motif) Ligand 2 (CCL2) interaction partners

1. Blocking androgen receptor signaling in cancer-associated fibroblasts -like cells increases prostate cancer cell migration mediated by increased secretion of CCL2 and CXCL8.

2. No association was observed between the CCL2 rs1024611 polymorphism and benign prostatic hyperplasia in Chinese patients.

3. Oligo-Fucoidan supplementation increases cancer cell death and attenuates the adverse effects induced by etoposide that decreases production of the pro-inflammatory cytokine IL-6 and chemokine CCL2/MCP-1.

4. NFAT5-knockout mouse FLSs also showed decreased expressions of TF and CCL2.

5. The -2518 A/G polymorphism of the monocyte chemoattractant protein-1 as a candidate genetic predisposition factor.

6. Study findings indicate a potential role for serum level of MCP-1 in combination with CTRP3 and CTRP9 as a diagnostic and prognostic tool in type 2 diabetes (T2D) and coronary artery disease as a complication of T2D in Egyptian postmenopausal female patients. Negative correlation between MCP-1 and CTRP9 proposes that the anti-inflammatory action of CTRP9 results from reducing MCP-1 production.

7. We found that pro-inflammatory cytokines IL-6 and CCL2 suppressed PER2 gene expression. Mechanistic studies further revealed that IL-6/STAT3/NFkappaB p50 and CCL2/PI3K/AKT signaling pathways suppressed PER2 gene expression in both phenotypically normal MCF-10A cells as well as MCF-7 breast cancer cells.

8. the patterns of HBP regulation of the expression of the adhesion molecular VCAM-1 were similar to those seen in MCP-1 after pretreatment with inhibitors.

9. Serum MCP-1 expression was significantly decreased in patients with UGIB and correlated with blood lipid level.

10. The aim was to determine the performance of urine EGF, MCP-1 or their ratio at baseline as biomarkers to predict complete remission, and the relationship of these mediators with subsequent renal function 24months later in primary glomerulonephritis.

11. MCP-1 is independently associated with coronary artery atherosclerosis among emergency department patients with chest pain.

12. In conclusion, AA genotype may be a protective factor against CKD susceptibility in Caucasians. AG genotype may be a risk factor for CKD risk in Caucasians.

13. Low serum levels of CCL2 shows a significant association with fatal or new non-fatal MI.

14. abnormal lamin. proteins trigger paracrine senescence through GATA4-dependent pathway in human mesenchymal stem cells.

15. During radical gastric cancer surgery, mRNA expression of interleukin-6 (IL-6), CC-chemokine ligand-2 and IL-1beta increased in adipose tissue intra-operatively (P < 0.05), equally both adjacent and remote from the tumour site.

16. Studies show an elevated serum level of CCL2 in hepatocellular carcinoma (HCC). Further results suggest that elevated CCL2 level could contribute to DPP4-induced tumor angiogenesis in high fat diet model of HCC development.

17. Vitamin D has anti-inflammatory effects in monocytes of Addison's Disease (AD) patients affecting CCL-2, IL6 and CD14. Of note is the weak CD14 expression in monocytes of AD patients compared to health controls (HC), which can be corrected by in vitro vitamin D treatment. We found that CD14 expression is altered in HC, with differences in relation to HLA haplotypes.We found higher CCL-2 expression in carriers of risk-HLA.

18. High CCL2 expression promotes breast cancer lung metastasis.

19. Our study suggests that MCP-1 mediated pathways could be potential therapeutic targets for the treatment of TNBC, and could reduce cancer health disparities.

20. Our study revealed that CCL2 and CCL4 expression levels could serve as potential prognostic biomarkers and therapeutic targets for non small cell lung cancer patients

Mouse (Murine) Chemokine (C-C Motif) Ligand 2 (CCL2) interaction partners

1. work demonstrates that MCP-1 has a role in PTH's catabolic effects on bone including monocyte and macrophage recruitment, osteoclast formation, bone resorption, and cortical and trabecular bone loss.

2. Adipose tissue MCP1 deficiency attenuates high fat diet-enhanced pulmonary metastasis of Lewis lung carcinoma.

3. These data provide a direct link between TRPML2 activation, CCL2 release and stimulation of macrophage migration in the innate immune response.

4. High CCL2 expression promotes breast cancer lung metastasis.

5. results showed elevated expression of Syk in neutrophils and CD11c + DC which was linked with increased IL-6/MCP-1 in CD11c + DCs, and iNOS, NOX2 and nitrotyrosine in neutrophils during sepsis-induced acute kidney injury.

6. CXCL1, CXCL2 and CCL2 binding to the glomerular endothelial glycocalyx appears differentially mediated by specific Heparan sulfate domains.

7. Targeting a reduction of MCP-1 opens the door to a better understanding of the mechanistic consequences of ceramide accumulation.

8. CCL2 played important roles in regulating platelet function and arterial thrombosis through the PKCalpha-P38MAPK-HSP27 pathway.

9. these results suggested that the IL-1beta-induced recruitment of monocyte/macrophage lineage cells to inflamed synovial membranes in TMJ was further augmented by the cell-cell interaction-induced secretion of MCP-1 from the inflammation site, possibly resulting in prolonged inflammatory responses in TMJ synovial tissue.

10. NOX4 is induced in early alcoholic liver injury and regulates CCR2/CCL2 mRNA stability thereby promoting recruitment of inflammatory cells and production of proinflammatory cytokines.

11. Ccl2-Ccr2 signaling recruits a distinct fetal microchimeric population that rescues delayed maternal wound healing.

12. itration reduced the potential of CCL2 to stimulate monocyte migration in diffusion gradient chemotaxis assays (p < 0.05). This was consistent with a trend towards reduced affinity of the nitrated chemokine for its cognate receptor CCR2b.

13. CCL2 enables the prolonged Mesenchymal stem cells-T cell interactions needed for sufficient suppression of autoreactive T cells

14. The data highlight Klf4 as an essential MCPIP1-dependent modulator of innate immunity that protects against excessive and self-destructive inflammation.

15. a novel mechanism that contributes to the EMT and metastatic phenotype observed in a subset of ADT-resistant prostate cancer, where the CCL2 is stimulated through the inactivated of AR-mediated SPDEF.

16. Macrophage subtypes enhanced the osteogenesis in transwell setting and the transition from M1 to M2 was associated with an increase in bone anabolic factors CCL2/MCP-1, CCL5/RANTES and IGF-1 in vitro.

17. Axotomy Leads to Reduced Calcium Increase and Earlier Termination of CCL2 Release in Spinal Motoneurons.

18. Our results showed that MIF regulates MCP-1 expression in hepatocytes of injured liver via CD74, CD44, and p38 MAPK in an autocrine manner.

19. these studies identify a novel role for the microbiota in shaping immunity, which includes induction of CCL2 levels that control homeostatic trafficking of plasmacytoid dendritic cells

20. These studies show that elevated levels of CCL2 in the CNS through increased astrocyte expression can significantly interact with the behavioral effects of alcohol.

Pig (Porcine) Chemokine (C-C Motif) Ligand 2 (CCL2) interaction partners

1. these results provide novel insights into CCL2-mediated signaling mechanisms in the porcine endometrium at the maternal-fetal interface during early pregnancy

2. CXCL10 protein was detected in serum from pigs infected with a high virulence African swine fever virus isolate. Levels of CCL2 mRNA were increased in pigs infected with the high virulence isolate compared to a low virulence isolate.

3. Porcine CCL2 binding on Tuk4+SLA-II- but not on Tuk4-SLA-II+ cells was detected by using a CCL2-green fluorescence protein fusion protein.

4. The protective properties of flavonoids, such as EGCG, against endothelial inflammation may be regulated in part though induction of HO-1 and subsequent activator protein-1 signaling.

5. MCP-1 contributes to functional and structural impairment in the kidney in renal artery stenosis, mainly in the tubulointerstitial compartment

6. may contribute to xenograft rejection by attracting monocytes into the islets

7. Contrast media did not affect bone marrow cell viability/MCP-1 secretion.

8. Porcine vessel wall injury via balloon arthroplasty upregulates expression of CCL2 by coronary artery transmural and perivascular cells in a sequential pattern.

9. in the aortic arch expression of monocyte chemoattractant protein 1 (MCP-1) was upregulated, compared with the thoracic aorta

10. Variable gene expression (eg, matrix metalloproteinase-9, CCL2 and Lp-PLA(2) mRNAs), both in regard to the arterial bed and duration of disease, was associated with variable plaque development and progression.

11. myocardial infarction induced proinflammatory gene and protein expression in peripheral blood mononuclear cells of tissue factor cyclo-oxygenase-2, monocyte chemoattractant protein-1 and CRP

Cow (Bovine) Chemokine (C-C Motif) Ligand 2 (CCL2) interaction partners

1. CCL2 plays a pivotal role in reproductive tissues and may support maternal-fetal interface to improve efficiency of pregnancy.

2. resence of type 2 diabetes negatively affects the work of cytokines and markers of fibrosis, as evidenced by higher levels of interleukin-1beta and monocyte chemoattractant protein-1, compared with patients without diabetes

3. Studied SNPs in the bovine toll-like receptor 4 (TLR4) and monocyte chemo attractant protein-1(CCL2) genes.

4. The LEP, IGF2 and CCL2 genes showed allelic expression imbalance in liver, kidney and pituitary glands of Polish Holstein-Friesian bulls.

5. immune cells and endothelial cells can interact cooperatively to increase CCL2 secretion in the corpus luteum

Rabbit Chemokine (C-C Motif) Ligand 2 (CCL2) interaction partners

1. Data show that peripheral blood endothelial progenitor cells can increase the expressions of chemokines CCL2 and CXCL12 and promote the migration of enhanced green fluorescent protein-positive bone marrow stromal cells to bone defect site.

2. Data show that the serum levels of mast cell tryptase, monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) decreased significantly in Dachengqi decoction treatment group.

3. measurements of CCL2 and macrophages can serve as new inflammatory biomarkers to evaluate the safety of promising novel microbicides for prevention of HIV.

4. Expression of MCP-1 was successfully inhibited by transfecting MCP-1 siRNA expression plasmid to the carotid artery, and the progression of atherosclerosis was restricted by RNAi-mediated silencing of MCP-1 expression.