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Mouse (Murine) CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305100
Ernst, Zhang, Hancock, Rutledge, Corless, Rollins: Biochemical and biologic characterization of murine monocyte chemoattractant protein-1. Identification of two functional domains. dans Journal of immunology (Baltimore, Md. : 1950) 1994
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Rat (Rattus) CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305099
Capsoni, Minonzio, Ongari, Zanussi: A new simplified single-filter assay for 'in vitro' evaluation of chemotaxis of 51Cr-labeled polymorphonuclear leukocytes. dans Journal of immunological methods 1989
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Human CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305101
Rollins, Stier, Ernst, Wong: The human homolog of the JE gene encodes a monocyte secretory protein. dans Molecular and cellular biology 1990
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Human CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN935624
Frøyland, Pedersen, Kvissel, Almaas, Pharo, Skålhegg, Mollnes, Rootwelt: Effect of acidosis on IL-8 and MCP-1 during hypoxia and reoxygenation in human NT2-N neurons. dans Brain research 2006
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Human CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN935639
Bogen, Dina, Gear, Levine: Dependence of monocyte chemoattractant protein 1 induced hyperalgesia on the isolectin B4-binding protein versican. dans Neuroscience 2009
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Mouse (Murine) CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN413594
Gray, Di Marco, Okabe, Szyndralewiez, Heitz, Montezano, de Haan, Koulis, El-Osta, Andrews, Chin-Dusting, Touyz, Wingler, Cooper, Schmidt, Jandeleit-Dahm: NADPH oxidase 1 plays a key role in diabetes mellitus-accelerated atherosclerosis. dans Circulation 2013
Mouse (Murine) CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN413564
Zhu, Daghini, Chade, Rodriguez-Porcel, Napoli, Lerman, Lerman: Role of oxidative stress in remodeling of the myocardial microcirculation in hypertension. dans Arteriosclerosis, thrombosis, and vascular biology 2006
A high frequency of CCL2 positive breast tumor cells and CD14 positive tumor associated macrophages are significant risk factors for rapid tumor recurrence.
Prognostic significance of monocyte chemoattractant protein-1 and CC chemokine receptor 2 in diffuse large B cell lymphoma.
CSF CCL2 levels are associated with the degree of medial temporal lobe and gray matter atrophy, and cognitive decline in Alzheimer's Disease
Both depression and posttraumatic stress disorder co-morbidity led to elevated levels of MIP-1beta and (iNOS, IL-33 and HO-1).
Results show that CCL2 from ductal carcinoma in situ (DCIS) fibroblasts is important for CCR2-mediated breast cancer survival and invasion.
LNMAT1-induced upregulation of CCL2 recruits macrophages into the tumor, which promotes lymphatic metastasis via VEGF-C excretion.
The expression of CX3CL1 and capital EM, Cyrilliccapital ES, Cyrilliccapital ER, Cyrillic-1 affect vital pulmonary capacity and forced expiratory volume in patients with asthma complicated by diabetes mellitus type 2.
Aberrant histone modifications, including acetylation and tri-methylation, were found both in global histone and specific MCP-1 gene locos in monocytes from patients with coronary artery disease
Alzheimer disease patients had higher plasma MCP-1 levels compared with mild cognitive impairment patients and controls, and severe AD patients had the highest levels.
CCL2 played important roles in regulating platelet function and arterial thrombosis through the PKCalpha-P38MAPK-HSP27 pathway.
Studied role of monocyte chemoattractant protein-1 (MCP-1) in migration of monocytes and lymphocytes during nickel induced contact hypersensitivity.
High chemokine CCL2 expression is associated with colorectal cancer.
NOX4 is induced in early alcoholic liver injury and regulates CCR2/CCL2 mRNA stability thereby promoting recruitment of inflammatory cells and production of proinflammatory cytokines.
study confirmed the connection between high uMCP-1 levels and poor prognosis and also disease activity in antineutrophil cytoplasmic autoantibody-Associated Vasculitis (AAV); it also suggests an association of the A/A genotype at position -2518 in the MCP-1 gene and poor prognosis in AAV
Given that IL-8, MIP-1beta, and MCP-1 are chemokines that play important roles in recruitment of immunocompetent cells for immune defense and tumor cell clearance, the observed lower levels of these markers with increasing PM2.5 exposure may provide insight into the mechanism by which DEE promotes lung cancer.
In lupus nephritis, urinary MCP-1 and TWEAK possess higher correlation coefficients with renal damage and larger areas under ROC curves than other markers for rapid discrimination of severe disease.
We propose that endogenous gC1qR/p33 physically interacts with MCP-1 causing stabilization of the MCP-1 protein and stimulation of its activity in human periodontal ligament cells, suggesting a novel gC1qR/p33-mediated pro-inflammatory mechanism of action.
berberine inhibited the expression of MCP-1 and IL-8 induced by LPS.
In Colombian systemic lupus erythematosus patients, urinary NGAL and MCP-1 in addition to anti-C1q antibodies were useful biomarkers for the identification of renal involvement and discrimination of active lupus nephritis.
These results provide evidence that necrotic cells induce the expression of CCL2/MCP-1 and CCL20/MIP-3alpha in glioblastoma cells through activation of NF-kappaB and AP-1 and facilitate the infiltration of microglia into tumor tissues.
Targeting a reduction of MCP-1 opens the door to a better understanding of the mechanistic consequences of ceramide accumulation.
these results suggested that the IL-1beta-induced recruitment of monocyte/macrophage lineage cells to inflamed synovial membranes in TMJ was further augmented by the cell-cell interaction-induced secretion of MCP-1 from the inflammation site, possibly resulting in prolonged inflammatory responses in TMJ synovial tissue.
Ccl2-Ccr2 signaling recruits a distinct fetal microchimeric population that rescues delayed maternal wound healing.
itration reduced the potential of CCL2 to stimulate monocyte migration in diffusion gradient chemotaxis assays (p < 0.05). This was consistent with a trend towards reduced affinity of the nitrated chemokine for its cognate receptor CCR2b.
CCL2 enables the prolonged Mesenchymal stem cells-T cell interactions needed for sufficient suppression of autoreactive T cells
The data highlight Klf4 as an essential MCPIP1-dependent modulator of innate immunity that protects against excessive and self-destructive inflammation.
a novel mechanism that contributes to the EMT and metastatic phenotype observed in a subset of ADT-resistant prostate cancer, where the CCL2 is stimulated through the inactivated of AR-mediated SPDEF.
Macrophage subtypes enhanced the osteogenesis in transwell setting and the transition from M1 to M2 was associated with an increase in bone anabolic factors CCL2/MCP-1, CCL5/RANTES and IGF-1 in vitro.
Axotomy Leads to Reduced Calcium Increase and Earlier Termination of CCL2 Release in Spinal Motoneurons.
Our results showed that MIF regulates MCP-1 expression in hepatocytes of injured liver via CD74, CD44, and p38 MAPK in an autocrine manner.
these studies identify a novel role for the microbiota in shaping immunity, which includes induction of CCL2 levels that control homeostatic trafficking of plasmacytoid dendritic cells
These studies show that elevated levels of CCL2 in the CNS through increased astrocyte expression can significantly interact with the behavioral effects of alcohol.
Topical application of glycolic acid suppresses the UVB induced IL-6, IL-8, MCP-1 and COX-2 inflammation by modulating NF-kappaB signaling pathway in mouse skin.
Study demonstrated that CD36 deletion regulated MCP-1 expression at the transcriptional level by changing the acetylation of histones binding to the MCP-1 promoters in hepatocytes, promoting macrophage migration to the liver, and aggravating hepatic inflammatory response and fibrosis.
Despite higher caloric intake and elevated body weights, carbohydrate restriction lowered serum MCP-1 levels, reduced prostate macrophage infiltration, reduced prostate weight, but failed to slow adenocarcinoma development.
Data indicate that ASC-J9(R) can suppress CD4+ T cell migration via decreasing the cytokine CCL2 in vitro and in vivo.
PDAC responds to radiotherapy by producing CCL2, which recruits Ly6C(+)CCR2(+) monocytes to support tumor proliferation and neovascularization after radiotherapy.
Chemokine receptor 2 (CCR2(+)) monocytes invade the hippocampus between 1 and 3 d after SE. In contrast, only an occasional CD3(+) T lymphocyte was encountered 3 d after SE. The initial cellular sources of the chemokine CCL2, a ligand for CCR2, included perivascular macrophages and microglia. The induction of the proinflammatory cytokine IL-1beta was greater in FACS-isolated microglia than in brain-invading monocytes
these results provide novel insights into CCL2-mediated signaling mechanisms in the porcine endometrium at the maternal-fetal interface during early pregnancy
CXCL10 protein was detected in serum from pigs infected with a high virulence African swine fever virus isolate. Levels of CCL2 mRNA were increased in pigs infected with the high virulence isolate compared to a low virulence isolate.
Porcine CCL2 binding on Tuk4+SLA-II- but not on Tuk4-SLA-II+ cells was detected by using a CCL2-green fluorescence protein fusion protein.
The protective properties of flavonoids, such as EGCG, against endothelial inflammation may be regulated in part though induction of HO-1 and subsequent activator protein-1 signaling.
MCP-1 contributes to functional and structural impairment in the kidney in renal artery stenosis, mainly in the tubulointerstitial compartment
may contribute to xenograft rejection by attracting monocytes into the islets
Contrast media did not affect bone marrow cell viability/MCP-1 secretion.
Porcine vessel wall injury via balloon arthroplasty upregulates expression of CCL2 by coronary artery transmural and perivascular cells in a sequential pattern.
in the aortic arch expression of monocyte chemoattractant protein 1 (MCP-1) was upregulated, compared with the thoracic aorta
Variable gene expression (eg, matrix metalloproteinase-9, CCL2 and Lp-PLA(2) mRNAs), both in regard to the arterial bed and duration of disease, was associated with variable plaque development and progression.
myocardial infarction induced proinflammatory gene and protein expression in peripheral blood mononuclear cells of tissue factor cyclo-oxygenase-2, monocyte chemoattractant protein-1 and CRP
CCL2 plays a pivotal role in reproductive tissues and may support maternal-fetal interface to improve efficiency of pregnancy.
resence of type 2 diabetes negatively affects the work of cytokines and markers of fibrosis, as evidenced by higher levels of interleukin-1beta and monocyte chemoattractant protein-1, compared with patients without diabetes
Studied SNPs in the bovine toll-like receptor 4 (TLR4) and monocyte chemo attractant protein-1(CCL2) genes.
The LEP, IGF2 and CCL2 genes showed allelic expression imbalance in liver, kidney and pituitary glands of Polish Holstein-Friesian bulls.
immune cells and endothelial cells can interact cooperatively to increase CCL2 secretion in the corpus luteum
Data show that peripheral blood endothelial progenitor cells can increase the expressions of chemokines CCL2 and CXCL12 and promote the migration of enhanced green fluorescent protein-positive bone marrow stromal cells to bone defect site.
Data show that the serum levels of mast cell tryptase, monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) decreased significantly in Dachengqi decoction treatment group.
measurements of CCL2 and macrophages can serve as new inflammatory biomarkers to evaluate the safety of promising novel microbicides for prevention of HIV.
Expression of MCP-1 was successfully inhibited by transfecting MCP-1 siRNA expression plasmid to the carotid artery, and the progression of atherosclerosis was restricted by RNAi-mediated silencing of MCP-1 expression.
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.
C-C motif chemokine 2
, monocyte chemoattractant protein 1
, monocyte chemoattractant protein-1
, monocyte chemotactic and activating factor
, monocyte chemotactic protein 1
, monocyte secretory protein JE
, small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je)
, small inducible cytokine subfamily A (Cys-Cys), member 2
, small-inducible cytokine A2
, platelet-derived growth factor-inducible protein JE
, small inducible cytokine A2
, immediate-early serum-responsive JE protein
, immediate-early serum-responsive protein JE
, small inducible gene JE
, acidic seminal fluid protein
, monocyte chemotactic protein 1A
, chemokine CCL2/MCP-1
, Monocyte chemoattractant protein 1
, Monocyte chemotactic protein 1
, Small-inducible cytokine A2