Checkpoint with Forkhead and Ring Finger Domains Produits
(Checkpoint with Forkhead and Ring Finger Domains (CHFR))
Catégories
E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating ubc13-mms2 (ube2n-ube2v2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress (By similarity).
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Catégories Checkpoint with Forkhead and Ring Finger Domains en vedette
Checkpoint with Forkhead and Ring Finger Domains Anticorps
High quality antibodies with extensive validation data.
Checkpoint with Forkhead and Ring Finger Domains Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
Checkpoint with Forkhead and Ring Finger Domains recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
ELISA, WB, IHC (p), RNAi
Validations
- (7)
- (6)
N° du produit
ABIN565913
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
ELISA, WB, IHC
Validations
- (3)
N° du produit
ABIN7151005
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
ELISA, WB
Validations
- (3)
N° du produit
ABIN527639
Quantité
100 μg
Fiche technique
Fiche technique
Checkpoint with Forkhead and Ring Finger Domains recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6234620
Quantité
96 tests
Fiche technique
Fiche technique
Checkpoint with Forkhead and Ring Finger Domains recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1349312
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1349314
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
N° du produit
ABIN3091433
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits Checkpoint with Forkhead and Ring Finger Domains
: "Expression level of the mitotic checkpoint protein and G2-M cell cycle regulators and prognosis in gastrointestinal stromal tumors in the stomach." dans: Virchows Archiv : an international journal of pathology, Vol. 460, Issue 2, pp. 163-9, (2012) (PubMed).: "CHFR protein regulates mitotic checkpoint by targeting PARP-1 protein for ubiquitination and degradation." dans: The Journal of biological chemistry, Vol. 287, Issue 16, pp. 12975-84, (2012) (PubMed).
: "Pathobiologic implications of methylation and expression status of Runx3 and CHFR genes in gastric cancer." dans: Medical oncology (Northwood, London, England), Vol. 28, Issue 2, pp. 447-54, (2011) (PubMed).
: "Loss of CHFR in human mammary epithelial cells causes genomic instability by disrupting the mitotic spindle assembly checkpoint." dans: Neoplasia (New York, N.Y.), Vol. 10, Issue 7, pp. 643-52, (2008) (PubMed).
: "Mechanism and pathobiologic implications of CHFR promoter methylation in gastric carcinoma." dans: World journal of gastroenterology : WJG, Vol. 14, Issue 32, pp. 5000-7, (2008) (PubMed).
: "Molecular analysis of primary gastric cancer, corresponding xenografts, and 2 novel gastric carcinoma cell lines reveals novel alterations in gastric carcinogenesis." dans: Human pathology, Vol. 38, Issue 6, pp. 903-13, (2007) (PubMed).
: "Altered expression of the early mitotic checkpoint protein, CHFR, in breast cancers: implications for tumor suppression." dans: Cancer research, Vol. 67, Issue 13, pp. 6064-74, (2007) (PubMed).
: "Chfr defines a mitotic stress checkpoint that delays entry into metaphase." dans: Nature, Vol. 406, Issue 6794, pp. 430-5, (2000) (PubMed).
Synonymes et noms alternatifs relatifs à Checkpoint with Forkhead and Ring Finger Domains
checkpoint with forkhead and ring finger domains (CHFR), checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase (chfr), checkpoint with forkhead and ring finger domains (Chfr), checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase L homeolog (chfr.L), 5730484M20Rik, C230082M18, CHFR, fc43f10, RNF116, rnf116, RNF196, rnf196, si:dkey-69h6.7, wu:fc43f10Protein level used designations for Checkpoint with Forkhead and Ring Finger Domains
- E3 ubiquitin-protein ligase CHFR
- RING finger protein 196
- checkpoint with forkhead and RING finger domains protein
- checkpoint with forkhead and ring finger domains
- Checkpoint with forkhead and RING finger domains protein
- e3 ubiquitin-protein ligase CHFR-like
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