Profil protéine

Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3)\; such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. May regulate the SUPT5H transcriptional elongation properties. May be part of a pathway that is connected to a chloride current, possibly through cytoskeletal rearrangement. Methylates histone H2A and H4 'Arg-3' during germ cell development. Methylates histone H3 'Arg-8', which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage. Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR\; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation. Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity (By similarity). Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation (By similarity). Methylates HOXA9 (By similarity).

Alternative names and synonyms associated with PRMT5

• protein arginine methyltransferase 5 (PRMT5) anticorps
• protein arginine N-methyltransferase 5 (Prmt5) anticorps
• protein arginine methyltransferase 5 (Prmt5) anticorps
• protein arginine methyltransferase 5 (prmt5) anticorps
• protein arginine methyltransferase 5 L homeolog (prmt5.L) anticorps
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• putative arginine N-methyltransferase, type II (PRMT5) anticorps
• Skb1 family protein (prmt5) anticorps
• protein arginine N-methyltransferase 5 (LOC100115766) anticorps
• Protein arginine N-methyltransferase 5 (prmt-5) anticorps

• DDBDRAFT_0187422 anticorps
• DDBDRAFT_0235403 anticorps
• DDB_0187422 anticorps
• DDB_0235403 anticorps
• hrmt1l5 anticorps
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• hsl7 anticorps
• ibp72 anticorps
• jbp1 anticorps
• NV18830 anticorps
• si:zc14a17.2 anticorps
• skb1 anticorps
• skb1hs anticorps
• wu:fb95f10 anticorps
• zgc:110669 anticorps

Protein level used designations for PRMT5

72 kDa ICln-binding protein , HMT1 hnRNP methyltransferase-like 5 , SKB1 homolog , histone-arginine N-methyltransferase PRMT5 , jak-binding protein 1 , protein arginine N-methyltransferase 5 , shk1 kinase-binding protein 1 homolog , protein arginine methyltransferase 5 , Jak-binding protein 1 , putative arginine N-methyltransferase, type II , protein arginine methyltransferase , protein arginine N-methyltransferase 5-like