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These results begin to establish a role for SNF2L in the precise coordination of gene expression in granulosa cells during folliculogenesis and its broader implications in fertility.
Cancers are sensitive to SNF2L knockdown because, unlike their normal counterparts, they lack sufficient compensation from other family members.
The imitation switch protein SNF2L regulates steroidogenic acute regulatory protein (Montrer STAR Protéines) expression during terminal differentiation of ovarian granulosa cells.
In one family, four siblings with a psychotic illness and their unaffected mother each carry a novel private missense variant in the SMARCA1 gene on the X chromosome.
Depletion of a chromatin remodeler, SMARCA1, in cancer cell lines promoted their growth.
The results suggest that the cAMP-response element consensus sequence in the SNF2L proximal promoter most likely confers constitutive activation and regulation by cAMP in neural cells.
The effect of SNF2L depletion on gene expression portray the cell in a state of activated Wnt (Montrer WNT2 Protéines) signaling with increased proliferation and locomotion. High levels of SNF2L expression in normal melanocytes contrast with undetectable expression in melanoma.
expression profiling analyses revealed that SWI/SNF (Montrer SNRPA Protéines) likely antagonizes Polycomb (Montrer CBX2 Protéines) repressive complex 2, implicating this as one possible mechanism of tumor suppression
ISWI proteins Snf2H (Montrer SMARCA5 Protéines), Snf2L as well as Acf1 (Montrer BAZ1A Protéines) accumulate at UV-induced DNA damage sites within tens of seconds and reach a plateau after a few minutes.
a neuronal SNF2L variant inactivates chromatin remodeling
Brahma (Montrer SMARCA2 Protéines) and Brahma (Montrer SMARCA2 Protéines)/SWI2-related gene 1 have roles in hypoxic induction of the erythropoietin (Montrer EPO Protéines) gene
This study provides the first insight into the mechanisms that control basal expression of human SNF2L gene.
This gene encodes a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
, SNF2L-like protein
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a1-like
, probable global transcription activator SNF2L1-like
, ATP-dependent helicase SMARCA1
, DNA-dependent ATPase SNF2L
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1
, nucleosome-remodeling factor subunit SNF2L
, probable global transcription activator SNF2L1
, SNF2-like 1
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a1
, global transcription activator homologous sequence
, sucrose nonfermenting 2-like protein 1